PDB: 1toc Compound: thrombin Classification: COMPLEX (HYDROLASE/INHIBITOR) Entry date in PDB: 1997-07-23 Resolution [Å]: 3.10 R-Factor: 0.230

CHAIN: A SWISS-PROT/TREMBL: P00735    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Cow (Bos taurus) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: B SWISS-PROT/TREMBL: P00735    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Cow (Bos taurus) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: C SWISS-PROT/TREMBL: P00735    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Cow (Bos taurus) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: D SWISS-PROT/TREMBL: P00735    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Cow (Bos taurus) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: E SWISS-PROT/TREMBL: P00735    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Cow (Bos taurus) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: F SWISS-PROT/TREMBL: P00735    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Cow (Bos taurus) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: G SWISS-PROT/TREMBL: P00735    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Cow (Bos taurus) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: H SWISS-PROT/TREMBL: P00735    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Cow (Bos taurus) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: R SWISS-PROT/TREMBL: P56409    KEYWORD: 3D-structure    Repeat    Serine protease inhibitor    SCOP: g.8.1.2 Small proteins    BPTI-like    BPTI-like    Soft tick anticoagulant proteins    Ornithodorin    Soft tick (Ornithodoros moubata) SCOP: g.8.1.2 Small proteins    BPTI-like    BPTI-like    Soft tick anticoagulant proteins    Ornithodorin    Soft tick (Ornithodoros moubata) GO:  serine-type endopeptidase inhibitor activity    CHAIN: S SWISS-PROT/TREMBL: P56409    KEYWORD: 3D-structure    Repeat    Serine protease inhibitor    SCOP: g.8.1.2 Small proteins    BPTI-like    BPTI-like    Soft tick anticoagulant proteins    Ornithodorin    Soft tick (Ornithodoros moubata) SCOP: g.8.1.2 Small proteins    BPTI-like    BPTI-like    Soft tick anticoagulant proteins    Ornithodorin    Soft tick (Ornithodoros moubata) GO:  serine-type endopeptidase inhibitor activity    CHAIN: T SWISS-PROT/TREMBL: P56409    KEYWORD: 3D-structure    Repeat    Serine protease inhibitor    SCOP: g.8.1.2 Small proteins    BPTI-like    BPTI-like    Soft tick anticoagulant proteins    Ornithodorin    Soft tick (Ornithodoros moubata) SCOP: g.8.1.2 Small proteins    BPTI-like    BPTI-like    Soft tick anticoagulant proteins    Ornithodorin    Soft tick (Ornithodoros moubata) GO:  serine-type endopeptidase inhibitor activity    CHAIN: U SWISS-PROT/TREMBL: P56409    KEYWORD: 3D-structure    Repeat    Serine protease inhibitor    SCOP: g.8.1.2 Small proteins    BPTI-like    BPTI-like    Soft tick anticoagulant proteins    Ornithodorin    Soft tick (Ornithodoros moubata) SCOP: g.8.1.2 Small proteins    BPTI-like    BPTI-like    Soft tick anticoagulant proteins    Ornithodorin    Soft tick (Ornithodoros moubata) GO:  serine-type endopeptidase inhibitor activity

Image Source: PDB

1etr H - percentage of sequence identity: 100
1h8d H - percentage of sequence identity: 86
1jou B - percentage of sequence identity: 87
1ucy H - percentage of sequence identity: 100
1vr1 H - percentage of sequence identity: 84
2hnt F - percentage of sequence identity: 94
null nu - percentage of sequence identity: 0