ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 18.2.1

Subclass Accession number: 5174
Subclass: 18.2.1

Type: HH alpha-alpha
DB: ArchDB95

Image coordinates:

Consensus coordinates:

Conserved Annotation
EC : 1.11 (>75 %)  1.11.1 (>75 %)  1.11.1.7 2.1 (>75 %)  2.1.1 (>75 %)  2.1.1.45
GO : GO:0004601 (>75 %)  GO:0008168 (>75 %)  GO:0016684 (>75 %)  GO:0016741 (>75 %)  GO:0042083 (>75 %)
SCOP : 48112 (>75 %)  48113 (>75 %)  48114 (>75 %)  55830 (>75 %)  55831 (>75 %)  55832 (>75 %)

Number of loops: 3

Average sequence ID (%) : 63.9 +/- -13.5
Average RMSD (Å) : 0.167 +/- 0.058

Consensus geometry

d (Å): 7

delta (°): 45-90

theta (°): 45-90

rho (°): 45-90

Consensus Sequence:	RHFGAEYXchppcYXcpGVDQL
(φψ)-conformation:	aapgpppabaappaplbeppaa

Pattern:	[Y]	[G]	[F]	[Q]	[W]	[R]	[H]	[F]	[G]	[A]	[E]	[Y]	x	[DN]	[CM]	[EKY]	[DST]	[DN]	[Y]	x	[GN]	[KQ]	[G]	[V]	[D]	[Q]	[L]	[AKQ]	[NR]	[IV]	[I]	[DNQ]	[KLT]	[I]	[KR]	[NT]
Conservation:	1.199	0.766	0.766	0.332	2.935	0.332	1.633	0.766	0.766	-0.102	0.332	1.199	-1.644	-0.295	-0.633	-1.307	-1.114	-0.292	1.199	-1.693	-0.508	-0.517	0.766	-0.102	0.766	0.332	-0.102	-1.259	-0.580	-0.314	-0.102	-0.921	-1.548	-0.102	-0.301	-0.650

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1f28_A_113	1f28	A	113	148	YGFQWRHFGAEYIDCKTNYIGQGVDQLANIIQKIRT	HHHHHHHBT-----TTS--TT-SB-HHHHHHHHHHH	aaaaaaapvxxxabaaxxapvxexxaaaaaaaaaaa
1hvy_A_135	1hvy	A	135	170	YGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKT	HHHHHHHBTS----TT---TT-SB-HHHHHHHHHHH	aaaaaaapgxxxabaapxapvbexxaaaaaaaaaaa
1j3k_C_430	1j3k	C	430	465	YGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKN	HHHHHHHBTS----TTS--TT-SB-HHHHHHHHHHH	aaaaaaapvxxxabaaxxapvbexxaaaaaaaaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1f28_A_113	1f28	A	UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE	Y - 113
1f28_A_113	1f28	A	F89S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN -9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID	Y - 113
1hvy_A_135	1hvy	A	UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE	Y - 135
1j3k_C_430	1j3k	C	UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE	Y - 430

Clusters included in this Subclass