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Information on SUBCLASS 1.2.21
Subclass Accession number: 8157
Subclass: 1.2.21 PSSM
Type: HE alpha-beta
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 2.1 (>75 %)  2.1.1 (>75 %)  2.1.1.45
GO : GO:0008168 (>75 %)  GO:0016741 (>75 %)  GO:0042083 (>75 %)  
SCOP : 55830 (>75 %)  55831 (>75 %)  55832 (>75 %)  
 Number of loops: 3

Average sequence ID (%) : 68.5 +/- -21.2
Average RMSD (Å) : 0.200 +/- 0.000

Consensus geometry
d (Å): 7 delta (°): 135-180 theta (°): 135-180 rho (°): 180-225
Consensus Sequence: hXcLp
(φψ)-conformation: aalbb
Pattern: [G][V][P][F][N][I][A][S][Y][AS][IL][FL][T][CHY][M][I][A][HQ][IV][CT][DGN][L][DKQ][P][AG][DQ][F][I][H][TV][LM][G][DN][AC][H][IV][Y]
Conservation:0.929-0.1961.4920.9290.929-0.196-0.196-0.1961.492-1.032-0.753-1.0830.366-1.3220.366-0.196-0.196-0.515-0.471-0.533-1.322-0.196-1.4471.492-0.970-0.8560.929-0.1962.055-1.195-0.6460.929-0.464-0.8002.055-0.4751.492
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1f28_A_2061f28   A206242GVPFNIASYALLTCMIAHVCDLDPGDFIHVMGDCHIYHHHHHHHHHHHHHHHHHHHTT-EEEEEEEEEEEEEEEaaaaaaaaaaaaaaaaaaaavbbxFbbbbxbaxbbbx
1hvy_A_2221hvy   A222258GVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYHHHHHHHHHHHHHHHHHHHTT-EEEEEEEEEEEEEEEaaaaaaaaaaaaaaaaaaaavbbwabbbxbbaxxbbx
1j3k_C_5171j3k   C517553GVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYHHHHHHHHHHHHHHHHHHHTT-EEEEEEEEEEEEEEEaaaaaaaaaaaaaaaaaaaalbbxabbbbbbaxbbbx
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1f28_A_2061f28   A     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE G - 206
1f28_A_2061f28   A     F89S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN -9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID G - 206
1f28_A_2061f28   A     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE V - 207
1f28_A_2061f28   A     F89S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN -9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID V - 207
1f28_A_2061f28   A     F89S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN -9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID F - 209
1f28_A_2061f28   A     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE N - 210
1f28_A_2061f28   A     F89S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN -9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID N - 210
1f28_A_2061f28   A     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE H - 240
1f28_A_2061f28   A     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE Y - 242
1f28_A_2061f28   A     F89S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN -9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID Y - 242
1hvy_A_2221hvy   A     D16TOMUDEX G - 222
1hvy_A_2221hvy   A     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE G - 222
1hvy_A_2221hvy   A     D16TOMUDEX V - 223
1hvy_A_2221hvy   A     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE V - 223
1hvy_A_2221hvy   A     D16TOMUDEX F - 225
1hvy_A_2221hvy   A     D16TOMUDEX N - 226
1hvy_A_2221hvy   A     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE N - 226
1hvy_A_2221hvy   A     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE H - 256
1hvy_A_2221hvy   A     D16TOMUDEX Y - 258
1hvy_A_2221hvy   A     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE Y - 258
1j3k_C_5171j3k   C     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE G - 517
1j3k_C_5171j3k   C     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE V - 518
1j3k_C_5171j3k   C     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE N - 521
1j3k_C_5171j3k   C     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE H - 551
1j3k_C_5171j3k   C     UMP2'-DEOXYURIDINE 5'-MONOPHOSPHATE Y - 553

Clusters included in this Subclass
CLUSTER: HE.2.136