PDB: 1dx5 Compound: thrombin light chain Classification: SERINE PROTEINASE Entry date in PDB: 2000-04-10 Resolution [Å]: 2.30 R-Factor: 0.200

CHAIN: A SWISS-PROT/TREMBL: P00734    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Disease mutation    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Polymorphism    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Human (Homo sapiens) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: B SWISS-PROT/TREMBL: P00734    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Disease mutation    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Polymorphism    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Human (Homo sapiens) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: C SWISS-PROT/TREMBL: P00734    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Disease mutation    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Polymorphism    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Human (Homo sapiens) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: D SWISS-PROT/TREMBL: P00734    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Disease mutation    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Polymorphism    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Human (Homo sapiens) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: I SWISS-PROT/TREMBL: P07204    KEYWORD: 3D-structure    Blood coagulation    Disease mutation    EGF-like domain    Endothelial cell    Glycoprotein    Hydroxylation    Polymorphism    Receptor    Repeat    Signal    Transmembrane    SCOP: g.3.11.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    EGF/Laminin    EGF-type module    Thrombomodulin, different EGF-like domains    Human (Homo sapiens) SCOP: g.3.11.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    EGF/Laminin    EGF-type module    Thrombomodulin, different EGF-like domains    Human (Homo sapiens) SCOP: g.3.11.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    EGF/Laminin    EGF-type module    Thrombomodulin, different EGF-like domains    Human (Homo sapiens) GO:  membrane    calcium ion binding    sugar binding    transmembrane receptor activity    blood coagulation    CHAIN: J SWISS-PROT/TREMBL: P07204    KEYWORD: 3D-structure    Blood coagulation    Disease mutation    EGF-like domain    Endothelial cell    Glycoprotein    Hydroxylation    Polymorphism    Receptor    Repeat    Signal    Transmembrane    SCOP: g.3.11.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    EGF/Laminin    EGF-type module    Thrombomodulin, different EGF-like domains    Human (Homo sapiens) SCOP: g.3.11.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    EGF/Laminin    EGF-type module    Thrombomodulin, different EGF-like domains    Human (Homo sapiens) SCOP: g.3.11.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    EGF/Laminin    EGF-type module    Thrombomodulin, different EGF-like domains    Human (Homo sapiens) GO:  membrane    calcium ion binding    sugar binding    transmembrane receptor activity    blood coagulation    CHAIN: K SWISS-PROT/TREMBL: P07204    KEYWORD: 3D-structure    Blood coagulation    Disease mutation    EGF-like domain    Endothelial cell    Glycoprotein    Hydroxylation    Polymorphism    Receptor    Repeat    Signal    Transmembrane    SCOP: g.3.11.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    EGF/Laminin    EGF-type module    Thrombomodulin, different EGF-like domains    Human (Homo sapiens) SCOP: g.3.11.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    EGF/Laminin    EGF-type module    Thrombomodulin, different EGF-like domains    Human (Homo sapiens) SCOP: g.3.11.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    EGF/Laminin    EGF-type module    Thrombomodulin, different EGF-like domains    Human (Homo sapiens) GO:  membrane    calcium ion binding    sugar binding    transmembrane receptor activity    blood coagulation    CHAIN: L SWISS-PROT/TREMBL: P07204    KEYWORD: 3D-structure    Blood coagulation    Disease mutation    EGF-like domain    Endothelial cell    Glycoprotein    Hydroxylation    Polymorphism    Receptor    Repeat    Signal    Transmembrane    SCOP: g.3.11.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    EGF/Laminin    EGF-type module    Thrombomodulin, different EGF-like domains    Human (Homo sapiens) SCOP: g.3.11.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    EGF/Laminin    EGF-type module    Thrombomodulin, different EGF-like domains    Human (Homo sapiens) SCOP: g.3.11.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    EGF/Laminin    EGF-type module    Thrombomodulin, different EGF-like domains    Human (Homo sapiens) GO:  membrane    calcium ion binding    sugar binding    transmembrane receptor activity    blood coagulation    CHAIN: M SWISS-PROT/TREMBL: P00734    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Disease mutation    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Polymorphism    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Human (Homo sapiens) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: N SWISS-PROT/TREMBL: P00734    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Disease mutation    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Polymorphism    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Human (Homo sapiens) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: O SWISS-PROT/TREMBL: P00734    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Disease mutation    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Polymorphism    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Human (Homo sapiens) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: P SWISS-PROT/TREMBL: P00734    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Disease mutation    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Polymorphism    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Human (Homo sapiens) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis

Image Source: PDB

Loops in ArchDB40 clusters

1dx5_I_413 - HA => SUBCLASS : 2.1.1
1dx5_I_359 - HA => SUBCLASS : 2.2.1
1dx5_I_376 - HA => SUBCLASS : 2.2.29
1dx5_I_436 - HA => SUBCLASS : 2.6.1
1dx5_I_436 - HA => SUBCLASS : 3.7.1
1dx5_I_359 - HA => SUBCLASS : 4.3.1
1dx5_I_398 - HA => SUBCLASS : 6.5.1
1dx5_I_407 - AR => SUBCLASS : 3.6.2
1dx5_I_368 - AR => SUBCLASS : 3.6.2

Loops in ArchDB95 clusters

1dx5_I_407 - AR => SUBCLASS : 3.17.1
1dx5_I_368 - AR => SUBCLASS : 4.5.1
1dx5_I_413 - HA => SUBCLASS : 2.1.1
1dx5_I_376 - HA => SUBCLASS : 2.2.17
1dx5_I_413 - HA => SUBCLASS : 3.2.1
1dx5_I_359 - HA => SUBCLASS : 4.2.1
1dx5_I_436 - HA => SUBCLASS : 5.3.1
1dx5_I_398 - HA => SUBCLASS : 7.1.1

Loops not clustered in ArchDB

1dx5_I_382 - AR
1dx5_I_394 - AR
1dx5_I_420 - EH
1dx5_I_444 - HA
1dx5_I_426 - HE

1adx - - percentage of sequence identity: 100
1dqb A - percentage of sequence identity: 97
1dx5 I - percentage of sequence identity: 100
1dx5 J - percentage of sequence identity: 100
1dx5 K - percentage of sequence identity: 100
1dx5 L - percentage of sequence identity: 100
1etr H - percentage of sequence identity: 87
1h8d H - percentage of sequence identity: 96
1jou B - percentage of sequence identity: 99
1ucy H - percentage of sequence identity: 85
1vr1 H - percentage of sequence identity: 96
1zaq - - percentage of sequence identity: 97
2adx - - percentage of sequence identity: 100
2hnt F - percentage of sequence identity: 100
null nu - percentage of sequence identity: 0