PDB: 4htc Compound: Alpha-thrombin complex with recombinant hirudin (v Classification: HYDROLASE(SERINE PROTEASE) Entry date in PDB: 1994-01-31 Resolution [Å]: 2.30 R-Factor: 0.173

CHAIN: H SWISS-PROT/TREMBL: P00734    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Disease mutation    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Polymorphism    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Human (Homo sapiens) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis    CHAIN: I SWISS-PROT/TREMBL: P09945    KEYWORD: 3D-structure    Multigene family    Serine protease inhibitor    Signal    Sulfation    SCOP: g.3.15.2 Small proteins    Knottins (small inhibitors, toxins, lectins)    Leech antihemostatic proteins    Hirudin-like    Hirudin    Leech (Hirudo medicinalis) GO:  serine-type endopeptidase inhibitor activity    CHAIN: L SWISS-PROT/TREMBL: P00734    KEYWORD: 3D-structure    Acute phase    Blood coagulation    Calcium-binding    Disease mutation    Gamma-carboxyglutamic acid    Glycoprotein    Hydrolase    Kringle    Plasma    Polymorphism    Repeat    Serine protease    Signal    Vitamin K    Zymogen    EC: 3.4.21.5 SCOP: b.47.1.2 All beta proteins    Trypsin-like serine proteases    Trypsin-like serine proteases    Eukaryotic proteases    Thrombin    Human (Homo sapiens) GO:  extracellular region    calcium ion binding    chymotrypsin activity    thrombin activity    trypsin activity    blood coagulation    proteolysis and peptidolysis

Image Source: PDB

Loops in ArchDB40 clusters

4htc_I_11 - AR => SUBCLASS : 1.2.2

Loops in ArchDB95 clusters

4htc_I_11 - AR => SUBCLASS : 1.1.5

Loops not clustered in ArchDB

4htc_I_21 - AR
4htc_I_38 - AR
4htc_I_14 - HA
4htc_I_26 - HA

1etr H - percentage of sequence identity: 87
1h8d H - percentage of sequence identity: 97
1hic - - percentage of sequence identity: 86
1hrt I - percentage of sequence identity: 87
1jou B - percentage of sequence identity: 99
1ucy H - percentage of sequence identity: 85
1vr1 H - percentage of sequence identity: 96
2hir - - percentage of sequence identity: 87
2hnt F - percentage of sequence identity: 100
3htc I - percentage of sequence identity: 100
4hir - - percentage of sequence identity: 86
5hir - - percentage of sequence identity: 87
6hir - - percentage of sequence identity: 86
null nu - percentage of sequence identity: 0