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Information on SUBCLASS 3.1.2
Subclass Accession number: 2267
Subclass: 3.1.2 PSSM
Type: HH alpha-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 3.1 (>75 %)  
 Number of loops: 42

Average sequence ID (%) : 13.8 +/- 15.2
Average RMSD (Å) : 0.693 +/- 0.203

Consensus geometry
d (Å): 11 delta (°): 90-135 theta (°): 45-90 rho (°): 180-225
Consensus Sequence: XXcXphX
(φψ)-conformation: aalbpaa
Pattern: x[adegknqrst]xx[dgknq]x[deknpst]xx[adekqrst]x
Conservation:-0.5070.367-0.560-0.3732.525-0.5480.851-0.542-1.0840.307-0.436
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1axn_*_1231axn   -134144YTVYKKSLGDDHHHHSS-HHHHaaaavbxaaaa
1axn_*_2071axn   -218228RNISQKDIVDSHHHHSS-HHHHaaaavbxaaaa
1axn_*_2851axn   -293303KKHYGYSLYSAHHHHSS-HHHHaaaavbxaaaa
1axn_*_511axn   -6272QAAYGKELKDDHHHHS--HHHHaaaalbxaaaa
1bl0_A_411bl0   A4959KKETGHSLGQYHHHHSS-HHHHaaaavbxaaaa
1bl0_A_911bl0   A99109KNYFDVPPHKYHHHHSS-HHHHaaaavbxaaaa
1ci9_A_1841ci9   A193203ERATGQPLAAAHHHHTS-HHHHaaaavbxaaaa
1cp2_A_2121cp2   A217227AEINKQTVIEYHHHTTS-HHHHaaaalbxaaaa
1dgw_A_1921dgw   A196206EASYDSPYDEIHHHHTS-HHHHaaaalbxaaaa
1eex_A_2291eex   A232242FTDGDDTPWSKHHHTT--HHHHaaaalbbaaaa
1ei5_A_1551ei5   A166176EAHTGRTLVDIHHHHTS-HHHHaaaavbxaaaa
1f2v_A_1041f2v   A109119AAEIGNTRSAAHHHHTS-HHHHaaaavbxaaaa
1fsu_*_931fsu   -97107QLLTGRYQIRTHHHH-S-HHHHaaaavbpaaaa
1g3q_A_2011g3q   A206216GTLEGIPAVKYHHHHTS-HHHHaaaavbpaaaa
1guq_A_1771guq   A190200FAEQKSPMLVDHHHHSS-HHHHaaaavbxaaaa
1gvj_A_4181gvj   A419429QSLLGYTPEELHHHHS--HHHHaaaavbxaaaa
1hdh_A_531hdh   A5767MLLTGTDHHIAHHTTSS-HHHHaaaavbxaaaa
1hwl_A_7141hwl   A718728REVLKTTTEAMHHTSSS-HHHHaaaalbbaaaa
1i27_A_4791i27   A479489TKKTGLSSEQTHHHH---HHHHaaaavxxaaaa
1ixc_A_201ixc   A2232AKRLHVSQPPIHHHHT--HHHHaaaavbxaaaa
1j9b_A_411j9b   A4858IADMGISVRALHHHHTS-HHHHaaaavbxaaaa
1je8_A_1771je8   A177187ARRLDITESTVHHHHTS-HHHHaaaalbxaaaa
1jpm_A_971jpm   A112122AQMCGLPLYQMHHHTTSBHHHHaaaavbxaaaa
1k20_A_1621k20   A172182AELAGVNLEEYHHHHTS-HHHHaaaavbxaaaa
1kbl_A_7671kbl   A772782QMTFGFSRDDAHHHHT--HHHHaaaavbxaaaa
1kqp_A_2201kqp   A221231ETELGISYDEIHHHHSS-HHHHaaaavbxaaaa
1l4u_A_331l4u   A3848EQRTGRSIADIHHHHSS-HHHHaaaagxxaaaa
1mc2_A_10021mc2   A10101020WQETGKNPVKNHHHH-S-HHHHaaaavxxaaaa
1mtp_A_521mtp   A5969TTLLGTDPAPLHHHHTS-HHHHaaaavbxaaaa
1muc_A_1021muc   A117127GKRLGLPVSELHHHHT-BHHHHaaaavbxaaaa
1n00_A_481n00   A5969AETYGEDLLKAHHHHSS-HHHHaaaavbxaaaa
1n9l_A_391n9l   A4252YAMTGYGPDEVHHHH---HHHHaaaavxbaaaa
1nvt_A_1601nvt   A171181AEKLNKKFGEEHHHHT--HHHHaaaalbxaaaa
1o82_A_21o82   A212AKEFGIPAAVAHHHH---HHHHaaaavxxaaaa
1oyj_A_1761oyj   A180190ERCGGFSVEEVHHHHT--HHHHaaaavbbaaaa
1pz1_A_2381pz1   A253263KTRYGKSVIHLHHHHS--HHHHaaaavbbaaaa
1q2w_A_2511q2w   A254264SAQTGIAVLDMHHHHT--HHHHaaaavbxaaaa
1qnr_A_2441qnr   A244254PDSWGTNYTWGHHHHT--STHHaaaavbxaaaa
1qzz_A_1371qzz   A138148AGRYGRPFWEDHHHHSS-HHHHaaaagbxaaaa
1rxw_A_2111rxw   A215225LKRLGLTREQLHHHHT--HHHHaaaavbbaaaa
1via_A_351via   A4050EQKFNQKVSEIHHHHTS-HHHHaaaalbxaaaa
3pmg_A_3903pmg   A401411LATRKQSVEDIHHHH-S-HHHHaaaalbxaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1axn_*_511axn   *     CACALCIUM ION D - 76
1axn_*_1231axn   *     CACALCIUM ION E - 148
1axn_*_2071axn   *     CACALCIUM ION I - 229
1axn_*_2071axn   *     CACALCIUM ION K - 230
1axn_*_2071axn   *     CACALCIUM ION G - 231
1axn_*_2071axn   *     CACALCIUM ION E - 232
1eex_A_2291eex   A     COYCO-(ADENIN-9-YL-PENTYL)-COBALAMIN D - 234
1eex_A_2291eex   A     COYCO-(ADENIN-9-YL-PENTYL)-COBALAMIN G - 235
1eex_A_2291eex   A     COYCO-(ADENIN-9-YL-PENTYL)-COBALAMIN D - 236
1eex_A_2291eex   A     COYCO-(ADENIN-9-YL-PENTYL)-COBALAMIN D - 237
1eex_A_2291eex   A     COYCO-(ADENIN-9-YL-PENTYL)-COBALAMIN K - 242
1fsu_*_931fsu   *     ALS2-AMINO-3-OXO-4-SULFO-BUTYRIC ACID P - 93
1fsu_*_931fsu   *     ALS2-AMINO-3-OXO-4-SULFO-BUTYRIC ACID S - 94
1fsu_*_931fsu   *     ALS2-AMINO-3-OXO-4-SULFO-BUTYRIC ACID R - 95
1fsu_*_931fsu   *     CACALCIUM ION R - 95
1fsu_*_931fsu   *     ALS2-AMINO-3-OXO-4-SULFO-BUTYRIC ACID S - 96
1g3q_A_2011g3q   A     ADPADENOSINE-5'-DIPHOSPHATE P - 201
1g3q_A_2011g3q   A     ADPADENOSINE-5'-DIPHOSPHATE A - 202
1g3q_A_2011g3q   A     ADPADENOSINE-5'-DIPHOSPHATE I - 203
1g3q_A_2011g3q   A     ADPADENOSINE-5'-DIPHOSPHATE R - 204
1g3q_A_2011g3q   A     ADPADENOSINE-5'-DIPHOSPHATE E - 205
1g3q_A_2011g3q   A     ADPADENOSINE-5'-DIPHOSPHATE T - 207
1g3q_A_2011g3q   A     ADPADENOSINE-5'-DIPHOSPHATE L - 208
1guq_A_1771guq   A     FEFE (III) ION E - 182
1guq_A_1771guq   A     FEFE (III) ION L - 198
1hdh_A_531hdh   A     FGL2-AMINOPROPANEDIOIC ACID P - 53
1hdh_A_531hdh   A     CACALCIUM ION P - 53
1hdh_A_531hdh   A     FGL2-AMINOPROPANEDIOIC ACID T - 54
1hdh_A_531hdh   A     CACALCIUM ION T - 54
1hdh_A_531hdh   A     FGL2-AMINOPROPANEDIOIC ACID R - 55
1hdh_A_531hdh   A     CACALCIUM ION R - 55
1hdh_A_531hdh   A     FGL2-AMINOPROPANEDIOIC ACID S - 56
1hwl_A_7141hwl   A     ADPADENOSINE-5'-DIPHOSPHATE E - 719
1hwl_A_7141hwl   A     ADPADENOSINE-5'-DIPHOSPHATE V - 720
1hwl_A_7141hwl   A     ADPADENOSINE-5'-DIPHOSPHATE K - 722
1hwl_A_7141hwl   A     FBI7-[4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL] -3,5-DIHYDROXY-HEPTANOIC ACID K - 735
1ixc_A_201ixc   A     MSESELENOMETHIONINE A - 20
1ixc_A_201ixc   A     MSESELENOMETHIONINE A - 21
1ixc_A_201ixc   A     MSESELENOMETHIONINE A - 22
1ixc_A_201ixc   A     MSESELENOMETHIONINE K - 23
1ixc_A_201ixc   A     MSESELENOMETHIONINE Q - 29
1ixc_A_201ixc   A     MSESELENOMETHIONINE P - 31
1ixc_A_201ixc   A     MSESELENOMETHIONINE I - 32
1ixc_A_201ixc   A     MSESELENOMETHIONINE T - 33
1ixc_A_201ixc   A     MSESELENOMETHIONINE R - 34
1j9b_A_411j9b   A     CSCESIUM ION E - 43
1je8_A_1771je8   A     MSESELENOMETHIONINE A - 177
1je8_A_1771je8   A     MSESELENOMETHIONINE R - 178
1je8_A_1771je8   A     MSESELENOMETHIONINE R - 179
1je8_A_1771je8   A     MSESELENOMETHIONINE L - 180
1je8_A_1771je8   A     MSESELENOMETHIONINE V - 189
1je8_A_1771je8   A     MSESELENOMETHIONINE H - 190
1je8_A_1771je8   A     MSESELENOMETHIONINE V - 191
1je8_A_1771je8   A     MSESELENOMETHIONINE K - 192
1jpm_A_971jpm   A     GOLGLYCEROL D - 109
1jpm_A_971jpm   A     GOLGLYCEROL Q - 113
1kqp_A_2201kqp   A     MGMAGNESIUM ION D - 220
1kqp_A_2201kqp   A     ADJNICOTINAMIDE-ADENINE-DINUCLEOTIDE-ADENYLATE INTERMEDIATE D - 220
1kqp_A_2201kqp   A     POPPYROPHOSPHATE 2- D - 220
1kqp_A_2201kqp   A     EDO1,2-ETHANEDIOL E - 221
1kqp_A_2201kqp   A     ADJNICOTINAMIDE-ADENINE-DINUCLEOTIDE-ADENYLATE INTERMEDIATE E - 223
1kqp_A_2201kqp   A     ADJNICOTINAMIDE-ADENINE-DINUCLEOTIDE-ADENYLATE INTERMEDIATE L - 224
1kqp_A_2201kqp   A     EDO1,2-ETHANEDIOL G - 225
1kqp_A_2201kqp   A     EDO1,2-ETHANEDIOL I - 226
1kqp_A_2201kqp   A     EDO1,2-ETHANEDIOL S - 227
1kqp_A_2201kqp   A     ADJNICOTINAMIDE-ADENINE-DINUCLEOTIDE-ADENYLATE INTERMEDIATE Y - 228
1kqp_A_2201kqp   A     POPPYROPHOSPHATE 2- Y - 228
1kqp_A_2201kqp   A     EDO1,2-ETHANEDIOL E - 230
1l4u_A_331l4u   A     MGMAGNESIUM ION D - 34
1mc2_A_10021mc2   A     IPAISOPROPYL ALCOHOL L - 1002
1mc2_A_10021mc2   A     IPAISOPROPYL ALCOHOL F - 1003
1mc2_A_10021mc2   A     IPAISOPROPYL ALCOHOL L - 1005
1mc2_A_10021mc2   A     IPAISOPROPYL ALCOHOL G - 1006
1mc2_A_10021mc2   A     IPAISOPROPYL ALCOHOL K - 1007
1mc2_A_10021mc2   A     IPAISOPROPYL ALCOHOL I - 1009
1mc2_A_10021mc2   A     IPAISOPROPYL ALCOHOL N - 1016
1mc2_A_10021mc2   A     IPAISOPROPYL ALCOHOL P - 1017
1mc2_A_10021mc2   A     IPAISOPROPYL ALCOHOL V - 1018
1n9l_A_391n9l   A     FMNFLAVIN MONONUCLEOTIDE F - 41
1nvt_A_1601nvt   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE K - 162
1oyj_A_1761oyj   A     GOLGLYCEROL F - 176
1oyj_A_1761oyj   A     GOLGLYCEROL Y - 177
1oyj_A_1761oyj   A     GOLGLYCEROL E - 180
1oyj_A_1761oyj   A     GOLGLYCEROL S - 186
1oyj_A_1761oyj   A     GOLGLYCEROL V - 187
1oyj_A_1761oyj   A     GOLGLYCEROL E - 188
1oyj_A_1761oyj   A     MGMAGNESIUM ION E - 189
1oyj_A_1761oyj   A     MGMAGNESIUM ION V - 190
1pz1_A_2381pz1   A     MSESELENOMETHIONINE F - 238
1pz1_A_2381pz1   A     MSESELENOMETHIONINE L - 242
1pz1_A_2381pz1   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE I - 261
1qnr_A_2441qnr   A     MABMANNOBIOSE S - 246
1qnr_A_2441qnr   A     GOLGLYCEROL S - 246
1qnr_A_2441qnr   A     MABMANNOBIOSE W - 247
1qnr_A_2441qnr   A     NAGN-ACETYL-D-GLUCOSAMINE N - 250
1qnr_A_2441qnr   A     NAGN-ACETYL-D-GLUCOSAMINE T - 252
1qnr_A_2441qnr   A     NAGN-ACETYL-D-GLUCOSAMINE W - 253
1qzz_A_1371qzz   A     SAMS-ADENOSYLMETHIONINE W - 146
1qzz_A_1371qzz   A     SAMS-ADENOSYLMETHIONINE S - 150
1via_A_351via   A     MSESELENOMETHIONINE S - 35
1via_A_351via   A     MSESELENOMETHIONINE L - 38
1via_A_351via   A     MSESELENOMETHIONINE I - 39
1via_A_351via   A     MSESELENOMETHIONINE K - 42
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1fsu_*_931fsu   * SALTHESE RESIDUES AND THE METAL ION STABILIZE THE SULFATE ESTER RESIDUE 91. TOGETHER WITH THE METAL BINDING SITE THIS FORMS THE CENTER OF THE CATALYTIC ACTIVE SITE.R - 95

Clusters included in this Subclass
CLUSTER: HH.2.25
CLUSTER: HH.2.96
CLUSTER: HH.3.116
CLUSTER: HH.3.21
CLUSTER: HH.3.44
CLUSTER: HH.4.13
CLUSTER: HH.4.19