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| Information on SUBCLASS 2.5.1 |
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Subclass Accession number: 8248
Subclass: 2.5.1 
Type: HE alpha-beta DB: ArchDB-EC Image coordinates: 
 Consensus coordinates:
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Number of loops: 25 Average sequence ID (%) : 12.1 +/- 16.1 Average RMSD (Å) : 0.732 +/- 0.214 Consensus geometry
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| Consensus Sequence: | XXXXXX |
| (φψ)-conformation: | aappbb |
| Pattern: | [adeknqst] | x | x | x | [aegknqst] | [agiklmt] | [dehkprt] | x | x |
| Conservation: | 1.257 | -0.717 | -0.593 | -0.748 | 1.687 | -0.672 | 0.970 | -0.423 | -0.760 |
| Loops included in this Subclass |
| Loop | PDB | Chain | Start | End | Sequence | Sec Struct | Ramachandran |
| 1ab4_*_403 | 1ab4 | - | 408 | 416 | TALVANPWQ | HHHHHS-EE | aaaaabpbx |
| 1ad3_A_63 | 1ad3 | A | 77 | 85 | LPDWAEDEP | HHHHHS-EE | aaaaapxxx |
| 1b9l_A_23 | 1b9l | A | 23 | 31 | EEEINNRQD | HHHHHS-EE | aaaaabxbx |
| 1bry_Y_11 | 1bry | Y | 20 | 28 | NLREALPYE | HHHHTS-EE | aaaaaxxba |
| 1e2k_A_306 | 1e2k | A | 317 | 325 | KRLRSMHVF | HHHHT-EEE | aaaaaxbxb |
| 1e2t_A_22 | 1e2t | A | 31 | 39 | AHNCAIPFE | HHHHHS-EE | aaaaaxxxb |
| 1ekq_A_257 | 1ekq | A | 259 | 267 | DVQEWATIE | HHHHH--EE | aaaaaxbbb |
| 1g5h_D_138 | 1g5h | D | 147 | 155 | NLLKTSGKL | HHHHH--EE | aaaaaxxbx |
| 1gx3_A_22 | 1gx3 | A | 31 | 39 | AHNRSIPFE | HHHHHS-EE | aaaaabxxb |
| 1ihu_A_265 | 1ihu | A | 265 | 273 | ADLAGLPTD | HHHHTS-EE | aaaaaxwbb |
| 1j9q_A_6 | 1j9q | A | 7 | 15 | AEIAALPRQ | HHHHHS-EE | aaaaaxxbb |
| 1kbl_A_383 | 1kbl | A | 384 | 392 | AALKAGEVI | HHHHHS-EE | aaaaaxxxa |
| 1l0l_B_407 | 1l0l | B | 415 | 423 | KKFVSGRKS | HHHHHS-EE | aaaaaxpbb |
| 1lyx_A_198 | 1lyx | A | 199 | 207 | KQANQIRIL | HHHHHS-EE | aaaaaxxbb |
| 1m5y_A_396 | 1m5y | A | 416 | 424 | EQRASAYVK | HHHHHS-EE | aaaaaxxbb |
| 1m6j_A_207 | 1m6j | A | 208 | 216 | EVAEATRIQ | HHHHHS-EE | aaaaaxxbx |
| 1me8_A_466 | 1me8 | A | 468 | 476 | QLQSKAKIT | HHHHH--EE | aaaaapbbb |
| 1mrj_*_11 | 1mrj | - | 20 | 28 | NLRKALPNE | HHHHTS-EE | aaaaaxwba |
| 1msw_D_690 | 1msw | D | 703 | 711 | AKLLAAEVK | HHHHHS-EE | aaaaaxbxb |
| 1ney_A_198 | 1ney | A | 199 | 207 | KAASELRIL | HHHHH--EE | aaaaaxxbx |
| 1np3_A_11 | 1np3 | A | 12 | 20 | SIIQGKKVA | HHHHTS-EE | aaaaabxbb |
| 1or8_A_208 | 1or8 | A | 211 | 219 | DVAIKEPLV | HHHHTS-EE | aaaaabpbb |
| 1q44_A_14 | 1q44 | A | 22 | 30 | ALISSLPKE | HHHHHS-EE | aaaaaxpbb |
| 1tph_1_198 | 1tph | 1 | 199 | 207 | AVAQSTRII | HHHHHS-EE | aaaaaxxbb |
| 3adk_*_2 | 3adk | - | 3 | 11 | EKLKKSKII | HHHHTS-EE | aaaaaxxbb |
| PDB ligands within a cut-off distance of 6 Å in this subclass |
| Loop | PDB | Chain | Ligands | Residue |
| 1ihu_A_265 | 1ihu | A | ADPADENOSINE-5'-DIPHOSPHATE | L - 275 |
| 1ihu_A_265 | 1ihu | A | ADPADENOSINE-5'-DIPHOSPHATE | F - 276 |
| 1lyx_A_198 | 1lyx | A | PGA2-PHOSPHOGLYCOLIC ACID | G - 209 |
| 1ney_A_198 | 1ney | A | FTRFLUOROTRYPTOPHANE | Y - 208 |
| 1ney_A_198 | 1ney | A | 13P1,3-DIHYDROXYACETONEPHOSPHATE | G - 209 |
| 1or8_A_208 | 1or8 | A | UNKUNKNOWN | L - 218 |
| 1or8_A_208 | 1or8 | A | UNKUNKNOWN | D - 220 |
| 1tph_1_198 | 1tph | 1 | PGHPHOSPHOGLYCOLOHYDROXAMIC ACID | G - 209 |
| Clusters included in this Subclass |
| CLUSTER: HE.1.16 |
| CLUSTER: HE.2.23 |
| CLUSTER: HE.2.80 |
| CLUSTER: HE.3.38 |
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