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Information on SUBCLASS 1.2.2
Subclass Accession number: 8824
Subclass: 1.2.2 PSSM
Type: HH alpha-alpha
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 54

Average sequence ID (%) : 11.2 +/- 14.5
Average RMSD (Å) : 0.548 +/- 0.156

Consensus geometry
d (Å): 7 delta (°): 45-90 theta (°): 90-135 rho (°): 90-135
Consensus Sequence: XXXXX
(φψ)-conformation: aabaa
Pattern: x[acfgilmvwy]x[adeknqrst]x[deknpqrst]xxx
Conservation:-1.177-0.165-0.3940.632-0.3802.367-0.169-0.330-0.384
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1aq0_A_591aq0   A6169NLAASPAAAHHHH-HHHHaaaabaaaa
1aqu_A_1931aqu   A195203DMKEDIRREHHHH-HHHHaaaabaaaa
1aup_*_331aup   -3543VVDAHPEYEHHHH-HHHHaaaabaaaa
1b4u_A_471b4u   A5260RFKADESAYHHHH-HHHHaaaabaaaa
1bol_A_721bol   A7684IKSKDSSLYHHHH-HHHHaaaabaaaa
1bxn_A_4391bxn   A450458AARWCGPLRHHHH-HHHHaaaabaaaa
1c4z_A_6251c4z   A628636LGDSHPVLYHHHHSHHHHaaaabaaaa
1c8k_A_7281c8k   A731739YYDRIPELRHHHH-HHHHaaaabaaaa
1e1o_A_1691e1o   A172180DLIANDKSRHHHH-HHHHaaaabaaaa
1e39_A_4231e39   A425433VRKSLSKIDHHHH-THHHaaaabaaaa
1e4m_M_501e4m   M5462FTHRYPNKSHHHHSHHHHaaaabaaaa
1e6y_B_24211e6y   B24212429PEFREPIKAHHHHSHHHHaaaabaaaa
1ffv_C_851ffv   C8795VQARLPLLAHHHH-HHHHaaaabaaaa
1fp2_A_1501fp2   A153161FLDKNPEYNHHHH-HHHHaaaabaaaa
1fzy_A_1241fzy   A129137HYLRDRESFHHHH-HHHHaaaabaaaa
1g12_A_1341g12   A141149LATMDPDKAHHHH-HHHHaaaabaaaa
1gk8_A_4371gk8   A448456ACKWSPELAHHHH-HHHHaaaabaaaa
1gxy_A_221gxy   A3644DFNMNAKLKHHHH-HHHHaaaabaaaa
1hna_*_1541hna   -166174NQVFEPSCLHHHH-HHHHaaaabaaaa
1ift_*_1611ift   -177185EAARFQYIEHHHHBHHHHaaaabaaaa
1izo_A_2471izo   A257265ALHEHPKYKHHHHSTHHHaaaabaaaa
1j7n_A_2271j7n   A233241LQLYAPEAFHHHH-HHHHaaaabaaaa
1j7n_A_7491j7n   A755763VQKNAPKTFHHHH-HHHHaaaabaaaa
1j93_A_1701j93   A175183LAFAEPKVLHHHH-HHHHaaaabaaaa
1j99_A_1841j99   A186194ELKQDTGRTHHHH-HHHHaaaabaaaa
1ju3_A_1851ju3   A194202AILNDVAGAHHHH-HHHHaaaabaaaa
1k8q_A_1541k8q   A162170AFSTNPKLAHHHH-HHHHaaaabaaaa
1khc_A_2961khc   A298306TFNKLVSYRHHHH-HHHHaaaabaaaa
1kvk_A_2431kvk   A253261RLIKFPEIMHHHHSHHHHaaaabaaaa
1l3s_A_7291l3s   A739747YFESFPGVKHHHH-HHHHaaaabaaaa
1l5r_A_7291l5r   A731739YYEALPELKHHHH-HHHHaaaaxaaaa
1lns_A_5761lns   A581589KYSKDFNVFHHHH-HHHHaaaabaaaa
1lw9_A_1371lw9   A138146WYNQTPNRAHHHHSHHHHaaaabaaaa
1lwy_A_1061lwy   A113121WGSVDSHFQHHHH-HHHHaaaabaaaa
1m2t_A_1641m2t   A165173EAARFNPILHHHHBHHHHaaaabaaaa
1mla_*_201mla   -2230MAASYPIVEHHHH-HHHHaaaabaaaa
1mrj_*_1591mrj   -160168EAARYKFIEHHHHBHHHHaaaabaaaa
1nj4_A_1621nj4   A172180LIRDVPNEYHHHH-HHHHaaaabaaaa
1nst_A_7781nst   A780788LLRTEPAKVHHHH-HHHHaaaabaaaa
1nw3_A_331nw3   A4452VCEEIPDLKHHHH-HHHHaaaabaaaa
1o0s_A_921o0s   A102110LQDRNEKLFHHHH-HHHHaaaabaaaa
1o26_A_1811o26   A194202FKEKCPWTFHHHH-HHHHaaaabaaaa
1pa2_A_2571pa2   A263271SFASNQTLFHHHH-HHHHaaaabaaaa
1q34_A_1241q34   A129137LYQENRREYHHHT-HHHHaaaabaaaa
1q44_A_2281q44   A230238ELKKQTEVEHHHHTHHHHaaaabaaaa
1qci_A_1601qci   A176184EAARFKYIEHHHH-HHHHaaaabaaaa
1qcq_A_1221qcq   A127135IYKTDRPKYHHHH-HHHHaaaabaaaa
1qgd_A_2971qgd   A314322YAKAYPQEAHHHH-HHHHaaaabaaaa
1u9a_A_1311u9a   A136144IYCQNRVEYHHHH-HHHHaaaabaaaa
1ual_A_2011ual   A216224TWLRRPELLHHHH-HHHHaaaabaaaa
1ygp_A_7731ygp   A790798EFHNQRSEWHHHH-HHHHaaaabaaaa
2aak_*_1242aak   -129137MYSESKREYHHHH-HHHHaaaabaaaa
2ahj_A_532ahj   A6270RAWTDPEFRHHHH-HHHHaaaabaaaa
2mas_A_1302mas   A135143AARLEPRIVHHHH-THHHaaaabaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1aqu_A_1931aqu   A     A3PADENOSINE-3'-5'-DIPHOSPHATE Y - 193
1aqu_A_1931aqu   A     A3PADENOSINE-3'-5'-DIPHOSPHATE K - 197
1e1o_A_1691e1o   A     GOLGLYCEROL L - 190
1e1o_A_1691e1o   A     GOLGLYCEROL R - 194
1e39_A_4231e39   A     HECHEME C K - 431
1e39_A_4231e39   A     HECHEME C D - 433
1e39_A_4231e39   A     HECHEME C K - 434
1e39_A_4231e39   A     HECHEME C Y - 435
1e39_A_4231e39   A     HECHEME C G - 437
1e39_A_4231e39   A     HECHEME C L - 438
1e4m_M_501e4m   M     GOLGLYCEROL I - 50
1e4m_M_501e4m   M     GOLGLYCEROL W - 51
1e4m_M_501e4m   M     GOLGLYCEROL D - 52
1e4m_M_501e4m   M     GOLGLYCEROL G - 53
1e4m_M_501e4m   M     GOLGLYCEROL F - 54
1e4m_M_501e4m   M     GOLGLYCEROL T - 55
1e4m_M_501e4m   M     ZNZINC ION H - 56
1e4m_M_501e4m   M     NAGN-ACETYL-D-GLUCOSAMINE R - 57
1e4m_M_501e4m   M     GOLGLYCEROL R - 57
1e4m_M_501e4m   M     NAGN-ACETYL-D-GLUCOSAMINE Y - 58
1e4m_M_501e4m   M     GOLGLYCEROL Y - 58
1e4m_M_501e4m   M     NAGN-ACETYL-D-GLUCOSAMINE P - 59
1e4m_M_501e4m   M     NAGN-ACETYL-D-GLUCOSAMINE N - 60
1e4m_M_501e4m   M     NAGN-ACETYL-D-GLUCOSAMINE K - 61
1fp2_A_1501fp2   A     HMO4'-HYDROXY-7-METHOXYISOFLAVONE F - 150
1fp2_A_1501fp2   A     SAHS-ADENOSYL-L-HOMOCYSTEINE W - 151
1fp2_A_1501fp2   A     HMO4'-HYDROXY-7-METHOXYISOFLAVONE W - 151
1fp2_A_1501fp2   A     SAHS-ADENOSYL-L-HOMOCYSTEINE F - 164
1fp2_A_1501fp2   A     HMO4'-HYDROXY-7-METHOXYISOFLAVONE F - 164
1fp2_A_1501fp2   A     SAHS-ADENOSYL-L-HOMOCYSTEINE M - 168
1fp2_A_1501fp2   A     HMO4'-HYDROXY-7-METHOXYISOFLAVONE M - 168
1fp2_A_1501fp2   A     SAHS-ADENOSYL-L-HOMOCYSTEINE A - 169
1izo_A_2471izo   A     HEMPROTOPORPHYRIN IX CONTAINING FE I - 247
1izo_A_2471izo   A     HEMPROTOPORPHYRIN IX CONTAINING FE S - 248
1izo_A_2471izo   A     HEMPROTOPORPHYRIN IX CONTAINING FE F - 250
1j99_A_1841j99   A     HGIMERCURY (II) IODIDE E - 196
1j99_A_1841j99   A     HGIMERCURY (II) IODIDE C - 199
1j99_A_1841j99   A     HGIMERCURY (II) IODIDE Q - 200
1k8q_A_1541k8q   A     C11UNDECYL-PHOSPHINIC ACID BUTYL ESTER Q - 154
1k8q_A_1541k8q   A     C11UNDECYL-PHOSPHINIC ACID BUTYL ESTER G - 155
1k8q_A_1541k8q   A     C11UNDECYL-PHOSPHINIC ACID BUTYL ESTER T - 157
1k8q_A_1541k8q   A     NAGN-ACETYL-D-GLUCOSAMINE S - 164
1k8q_A_1541k8q   A     NAGN-ACETYL-D-GLUCOSAMINE T - 165
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION L - 296
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION A - 297
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION N - 300
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION K - 307
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION H - 311
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION E - 314
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION K - 315
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION A - 316
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION V - 318
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION R - 319
1l3s_A_7291l3s   A     SUCSUCROSE M - 750
1l3s_A_7291l3s   A     SUCSUCROSE E - 751
1l3s_A_7291l3s   A     SUCSUCROSE V - 754
1l3s_A_7291l3s   A     SUCSUCROSE Q - 755
1l3s_A_7291l3s   A     SUCSUCROSE K - 758
1m2t_A_1641m2t   A     ADEADENINE S - 164
1m2t_A_1641m2t   A     ADEADENINE E - 165
1m2t_A_1641m2t   A     ADEADENINE R - 168
1m2t_A_1641m2t   A     GOLGLYCEROL N - 170
1m2t_A_1641m2t   A     GOLGLYCEROL P - 171
1m2t_A_1641m2t   A     GOLGLYCEROL I - 172
1m2t_A_1641m2t   A     GOLGLYCEROL W - 174
1m2t_A_1641m2t   A     GOLGLYCEROL R - 175
1m2t_A_1641m2t   A     GOLGLYCEROL A - 176
1m2t_A_1641m2t   A     GOLGLYCEROL R - 177
1m2t_A_1641m2t   A     GOLGLYCEROL Q - 178
1m2t_A_1641m2t   A     GOLGLYCEROL Y - 179
1m2t_A_1641m2t   A     GOLGLYCEROL N - 181
1mrj_*_1591mrj   *     ADNADENOSINE S - 159
1mrj_*_1591mrj   *     ADNADENOSINE E - 160
1mrj_*_1591mrj   *     ADNADENOSINE R - 163
1nst_A_7781nst   A     A3PADENOSINE-3'-5'-DIPHOSPHATE G - 778
1nst_A_7781nst   A     A3PADENOSINE-3'-5'-DIPHOSPHATE L - 781
1nst_A_7781nst   A     A3PADENOSINE-3'-5'-DIPHOSPHATE R - 782
1nst_A_7781nst   A     A3PADENOSINE-3'-5'-DIPHOSPHATE P - 785
1o0s_A_921o0s   A     TTNTARTRONATE Q - 98
1o0s_A_921o0s   A     TTNTARTRONATE L - 102
1o0s_A_921o0s   A     TTNTARTRONATE R - 105
1o0s_A_921o0s   A     TTNTARTRONATE N - 106
1o0s_A_921o0s   A     TTNTARTRONATE L - 109
1pa2_A_2571pa2   A     CACALCIUM ION F - 275
1pa2_A_2571pa2   A     HEMPROTOPORPHYRIN IX CONTAINING FE F - 275
1pa2_A_2571pa2   A     CACALCIUM ION M - 279
1pa2_A_2571pa2   A     HEMPROTOPORPHYRIN IX CONTAINING FE M - 279
1pa2_A_2571pa2   A     CACALCIUM ION M - 282
1pa2_A_2571pa2   A     HEMPROTOPORPHYRIN IX CONTAINING FE M - 282
1qci_A_1601qci   A     ADEADENINE I - 171
1qci_A_1601qci   A     ADEADENINE S - 175
1qci_A_1601qci   A     ADEADENINE E - 176
1qci_A_1601qci   A     ADEADENINE R - 179
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1e4m_M_501e4m   M ZNBZN BINDING SITE TOGETHER WITH THE SYMMETRY-RELATED EQUIVALENTS. ACTIVE SITE NUCLEOPHILE: GLU409 AT THE POSITION OF THE GENERAL ACID/BASE: GLN187H - 56
1ift_*_1611ift   * ACTACTIVE SITE RESIDUES OF RICIN A-CHAIN.E - 177
1ift_*_1611ift   * ACTACTIVE SITE RESIDUES OF RICIN A-CHAIN.R - 180

Clusters included in this Subclass
CLUSTER: HH.0.19
CLUSTER: HH.1.3
CLUSTER: HH.2.11