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Information on SUBCLASS 2.2.2
Subclass Accession number: 7164
Subclass: 2.2.2 PSSM
Type: EH beta-alpha
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 30

Average sequence ID (%) : 8.8 +/- 12.7
Average RMSD (Å) : 0.637 +/- 0.216

Consensus geometry
d (Å): 9 delta (°): 0-45 theta (°): 45-90 rho (°): 135-180
Consensus Sequence: XXhpXX
(φψ)-conformation: bbppaa
Pattern: [ehknqrstw]xx[adgknqst]xxxxx
Conservation:-0.040-0.737-1.0222.196-0.974-0.3600.2210.6790.036
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1b7g_O_1331b7g   O135143RVVSCNTTAEE--HHHHHbxxxaaaaa
1bkc_A_3921bkc   A392400KTILTKEADEE--HHHHHbxxxaaaaa
1c4k_A_6711c4k   A671679EKWSETAVKEE--HHHHHxxpxaaaaa
1d3y_A_2991d3y   A299307HPLKEQDIKEE--HHHHHbpxxaaaaa
1dj2_A_1231dj2   A123131HLLFDFHQEEE--HHHHHxxxxaaaaa
1dl5_A_551dl5   A5765TSSQPSLMAEE--HHHHHbxxxaaaaa
1dmu_A_2301dmu   A239247SVPNGLGLFEE--HHHHHbbpxaaaaa
1e1h_A_2101e1h   A212220FATDPAVTLEE--HHHHHbbxxaaaaa
1e1h_B_3301e1h   B330338FSVDKLKFDEE--HHHHHxbbxaaaaa
1fcq_A_2731fcq   A276284TDLSRADLEEE--HHHHHxxxxaaaaa
1g8p_A_1351g8p   A135143FEPGLLARAEE--HHHHHxbpbaaaaa
1gu7_A_1431gu7   A145153KLPNPAQSKEE--HHHHHxbxxaaaaa
1i1n_A_561i1n   A5765TISAPHMHAEE--HHHHHbxxxaaaaa
1i50_B_4041i50   B405413RLDLAGPLLEEE-HHHHHbbxbaaaaa
1iib_A_761iib   A7785EVIDSLLYGEE--HHHHHbxxpaaaaa
1iwe_A_1351iwe   A135143HLVFDFHQAEE--HHHHHxxxxaaaaa
1j2p_A_2221j2p   A222230KEVSPEELKEE--HHHHHbxxxaaaaa
1jg1_A_731jg1   A7381TVSAPHMVAEE--HHHHHbxxxaaaaa
1jhd_A_571jhd   A5765GFMNVADAMEE--HHHHHexxxaaaaa
1kw3_B_871kw3   B8795TRGDEALMQEE--HHHHHbxpxaaaaa
1l1l_A_441l1l   A4452RSENWDETVEE--HHHHHbxpbaaaaa
1lgt_A_881lgt   A8896TTGDASLAREE--HHHHHbxxxaaaaa
1lhp_A_541lhp   A5563QVLNSDELQEE--HHHHHbbxxaaaaa
1ltk_A_1381ltk   A139147VKANKEDVEEE--HHHHHbbxbaaaaa
1n62_B_2951n62   B297305WVEDRMENLEE--HHHHHbbxxaaaaa
1nwc_A_1301nwc   A132140VGGNCTVSLEE--HHHHHbxxpaaaaa
1oyg_A_441oyg   A4452SHITRHDMLEE--HHHHHxbxxaaaaa
1p16_A_151p16   A1523NKLDEEETKEE--HHHHHbxxxaaaaa
1pfq_A_411pfq   A4149KTYTLTDYLEE--HHHHHxxxxaaaaa
1qmq_A_2311qmq   A231239RPITSDEAKEE--HHHHHbxxxaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1bkc_A_3921bkc   A     INN3,N(D,L-[2-(HYDROXYAMINO-CARBONYL)METHYL]-4-METHYL PENTANOYL)L-3-(TERT-BUTYL)GLYCYL-L-ALANINE L - 401
1bkc_A_3921bkc   A     INN3,N(D,L-[2-(HYDROXYAMINO-CARBONYL)METHYL]-4-METHYL PENTANOYL)L-3-(TERT-BUTYL)GLYCYL-L-ALANINE V - 402
1bkc_A_3921bkc   A     INN3,N(D,L-[2-(HYDROXYAMINO-CARBONYL)METHYL]-4-METHYL PENTANOYL)L-3-(TERT-BUTYL)GLYCYL-L-ALANINE T - 403
1bkc_A_3921bkc   A     ZNZINC ION H - 405
1bkc_A_3921bkc   A     INN3,N(D,L-[2-(HYDROXYAMINO-CARBONYL)METHYL]-4-METHYL PENTANOYL)L-3-(TERT-BUTYL)GLYCYL-L-ALANINE H - 405
1bkc_A_3921bkc   A     ZNZINC ION E - 406
1bkc_A_3921bkc   A     INN3,N(D,L-[2-(HYDROXYAMINO-CARBONYL)METHYL]-4-METHYL PENTANOYL)L-3-(TERT-BUTYL)GLYCYL-L-ALANINE E - 406
1bkc_A_3921bkc   A     ZNZINC ION H - 409
1bkc_A_3921bkc   A     INN3,N(D,L-[2-(HYDROXYAMINO-CARBONYL)METHYL]-4-METHYL PENTANOYL)L-3-(TERT-BUTYL)GLYCYL-L-ALANINE H - 409
1dl5_A_551dl5   A     SAHS-ADENOSYL-L-HOMOCYSTEINE Y - 55
1dl5_A_551dl5   A     SAHS-ADENOSYL-L-HOMOCYSTEINE S - 56
1dl5_A_551dl5   A     SAHS-ADENOSYL-L-HOMOCYSTEINE T - 57
1dl5_A_551dl5   A     SAHS-ADENOSYL-L-HOMOCYSTEINE S - 58
1dl5_A_551dl5   A     SAHS-ADENOSYL-L-HOMOCYSTEINE S - 59
1dl5_A_551dl5   A     SAHS-ADENOSYL-L-HOMOCYSTEINE M - 64
1dmu_A_2301dmu   A     SEO2-MERCAPTOETHANOL L - 244
1dmu_A_2301dmu   A     SEO2-MERCAPTOETHANOL F - 247
1e1h_A_2101e1h   A     ZNZINC ION H - 222
1e1h_A_2101e1h   A     ZNZINC ION E - 223
1e1h_A_2101e1h   A     ZNZINC ION H - 226
1i1n_A_561i1n   A     SAHS-ADENOSYL-L-HOMOCYSTEINE A - 56
1i1n_A_561i1n   A     SAHS-ADENOSYL-L-HOMOCYSTEINE I - 58
1i1n_A_561i1n   A     SAHS-ADENOSYL-L-HOMOCYSTEINE H - 64
1iwe_A_1351iwe   A     IMPINOSINIC ACID D - 145
1jg1_A_731jg1   A     SAHS-ADENOSYL-L-HOMOCYSTEINE T - 73
1jg1_A_731jg1   A     SAHS-ADENOSYL-L-HOMOCYSTEINE V - 74
1jg1_A_731jg1   A     SAHS-ADENOSYL-L-HOMOCYSTEINE S - 75
1jg1_A_731jg1   A     SAHS-ADENOSYL-L-HOMOCYSTEINE V - 80
1ltk_A_1381ltk   A     AMPADENOSINE MONOPHOSPHATE K - 140
1ltk_A_1381ltk   A     MSESELENOMETHIONINE K - 143
1ltk_A_1381ltk   A     AMPADENOSINE MONOPHOSPHATE K - 143
1ltk_A_1381ltk   A     MSESELENOMETHIONINE E - 144
1ltk_A_1381ltk   A     MSESELENOMETHIONINE E - 147
1p16_A_151p16   A     PO4PHOSPHATE ION E - 19
1p16_A_151p16   A     MSESELENOMETHIONINE E - 21
1p16_A_151p16   A     PO4PHOSPHATE ION T - 22
1p16_A_151p16   A     MSESELENOMETHIONINE K - 23
1p16_A_151p16   A     PO4PHOSPHATE ION K - 23
1p16_A_151p16   A     MSESELENOMETHIONINE E - 24
1p16_A_151p16   A     GGUANOSINE-5'-MONOPHOSPHATE E - 24
1p16_A_151p16   A     MSESELENOMETHIONINE L - 25
1p16_A_151p16   A     GGUANOSINE-5'-MONOPHOSPHATE L - 25
1p16_A_151p16   A     MSESELENOMETHIONINE R - 26
1p16_A_151p16   A     PO4PHOSPHATE ION R - 26
1p16_A_151p16   A     GGUANOSINE-5'-MONOPHOSPHATE R - 26
1qmq_A_2311qmq   A     HEMPROTOPORPHYRIN IX CONTAINING FE L - 244
1qmq_A_2311qmq   A     LRBLAMBDA-BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE) -C9-ADAMANTANE RUTHENIUM (II) L - 244
1qmq_A_2311qmq   A     DRBDELTA-BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE)-C9-ADAMANTANE RUTHENIUM (II) L - 244
1qmq_A_2311qmq   A     HEMPROTOPORPHYRIN IX CONTAINING FE L - 245
1qmq_A_2311qmq   A     HEMPROTOPORPHYRIN IX CONTAINING FE L - 246
1qmq_A_2311qmq   A     LRBLAMBDA-BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE) -C9-ADAMANTANE RUTHENIUM (II) V - 247
1qmq_A_2311qmq   A     DRBDELTA-BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE)-C9-ADAMANTANE RUTHENIUM (II) V - 247
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1b7g_O_1331b7g   O CTOCATALYTIC SITE IN SUBUNIT OC - 139
1e1h_A_2101e1h   A S1AMONOMER A. S1 BINDING POCKET OF THE LC ACTIVE SITE. QUITE LARGE.T - 214
1e1h_A_2101e1h   A ZNAMONOMER A: ZN ENDOPEPTIDASE ACTIVE SITE. ZN (II) COORDINATED BY STANDARD HEXXH AND E OF THE THERMOLYSIN MOTIF. HIS A 222, HIS A 226 AND GLU B 261. GLU A 223 SHARES COORDINATION OF TYR C 249 O WITH ZN A 501.H - 222
1e1h_A_2101e1h   A ZNAMONOMER A: ZN ENDOPEPTIDASE ACTIVE SITE. ZN (II) COORDINATED BY STANDARD HEXXH AND E OF THE THERMOLYSIN MOTIF. HIS A 222, HIS A 226 AND GLU B 261. GLU A 223 SHARES COORDINATION OF TYR C 249 O WITH ZN A 501.E - 223
1e1h_A_2101e1h   A ZNAMONOMER A: ZN ENDOPEPTIDASE ACTIVE SITE. ZN (II) COORDINATED BY STANDARD HEXXH AND E OF THE THERMOLYSIN MOTIF. HIS A 222, HIS A 226 AND GLU B 261. GLU A 223 SHARES COORDINATION OF TYR C 249 O WITH ZN A 501.H - 226
1e1h_A_2101e1h   A S2AMONOMER A: S1 BINDING POCKET OF THE LC ACTIVE SITE.R - 230
1gu7_A_1431gu7   A BC7SO4 BINDING SITE FOR CHAIN AQ - 151
1qmq_A_2311qmq   A HEMHEM BINDING SITEL - 245

Clusters included in this Subclass
CLUSTER: EH.1.15
CLUSTER: EH.2.15
CLUSTER: EH.3.16