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Information on SUBCLASS 2.4.1
Subclass Accession number: 8240
Subclass: 2.4.1 PSSM
Type: HE alpha-beta
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 68

Average sequence ID (%) : 13.8 +/- 15.9
Average RMSD (Å) : 0.603 +/- 0.195

Consensus geometry
d (Å): 9 delta (°): 45-90 theta (°): 135-180 rho (°): 90-135
Consensus Sequence: pXXpXh
(φψ)-conformation: aababb
Pattern: [afgilmvwy]x[adegknqrst]xx[dehknpqrs]x[afgilmpvwy]x[acfilmptv]
Conservation:0.168-1.0200.496-0.780-0.2922.006-1.3590.974-0.3710.178
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a8p_*_1291a8p   -131140VYERFEKVVLHHHH-SEEEEaaaababbbb
1aog_A_3791aog   A382391ASKRYEVVAVHHHH-SEEEEaaaababbbb
1aqf_E_2791aqf   E282291ILEASDGIMVHHHH-SEEEEaaaaxabbbx
1b0a_A_2461b0a   A249256AAKRASYI..HHHH-SEE..aaaapabb..
1b0z_A_551b0z   A6877IRNHSDALVVHHHH-SEEEEaaaababxbx
1b7g_O_711b7g   O7483LIKTSDIVVDHHHH-SEEEEaaaaxabbxx
1ccw_B_1271ccw   B138147VLEAVNLPLQHHHH-SS-EEaaaababxbb
1cjc_A_881cjc   A91100LQDAYHAVVLHHHHSSEEEEaaaababbbx
1coz_A_151coz   A2433AKQLGDYLVVHHTTSSEEEEaaaababbbb
1d9e_A_11021d9e   A11051114VADVVDVIQLHHTT-SEEEEaaaababbbx
1d9e_D_40991d9e   D41054114VADVVDVIQLHHHH-SEEEEaaaababbbx
1dd9_A_2911dd9   A297306LFRATNNVICHHHH-SEEEEaaaababbbx
1dg9_A_811dg9   A8190DFVTFDYILCHHHH-SEEEEaaaaxabbbb
1dhp_A_1121dhp   A122131IAEHTDLPQIHHTT-SS-EEaaaabaxwbb
1dmr_*_1711dmr   -174183LAENTEVMVFHHHH-SEEEEaaaaxabbbb
1dnl_A_881dnl   A92101QIENNPRVSLHHHH--EEEEaaaabaxbbb
1dxh_A_901dxh   A97106LGRMYDAIEYHHHH-SEEEEaaaababbbb
1e6c_A_1261e6c   A143152YQDVAHYVVDHHHHH-SEEEaaaaxabbbx
1e8c_A_3991e8c   A401410AEEFADVAVVHHHH-SEEEEaaaababbbx
1eg7_A_12851eg7   A12911300ALKLADYVVTHHHH-SEEEEaaaababbbb
1esw_A_2741esw   A283292ALELFHLVRIHHHH-SEEEEaaaababbxb
1eu1_A_1711eu1   A174183VVENTDLMVFHHHH-SEEEEaaaaxabbbx
1f06_A_1231f06   A131140AAAVLAEHQQHHHH-SSEEEaaaaxaxbbb
1f07_A_1551f07   A161170AGEISDGALIHHHH-SEEEEaaaababbxb
1f0k_A_2481f0k   A251260AYAWADVVVCHHHH-SEEEEaaaaxabbbb
1f0x_A_3791f0x   A384393WRDKYEHHLLHHHH-SEEEEaaaababbbx
1f5a_A_3671f5a   A367376FFQKYKHYIVHHHH-SEEEEaaNababbbb
1fec_A_3781fec   A381390AAKKYDQVAVHHHH-SEEEEaaaababbbb
1ff9_A_591ff9   A6574EVAKHDLVISHHTTSSEEEEaaaababbbb
1fxp_A_10881fxp   A10911100VAEVADIIQIHHTT-SEEEEaaaaxabxxb
1g0h_A_1591g0h   A162169LRNKVKRV..HHHH-SEE..aaaababb..
1g8k_A_6851g8k   A690699QKDKYRFWLNHHHH-SEEEEaaaababxbx
1gdh_A_361gdh   A4251TAKSVDALLIHHTT-SEEEEaaaababbbb
1gq6_A_931gq6   A107116LLKANAAFLMHHHHSSEEEEaaaababbbx
1gup_A_1241gup   A141150LGKTYPWVQVHHHH-SEEEEaaaababbbx
1gy9_A_291gy9   A3847AVLRHQVVFLHHHHSSEEEEaaaaxabbbb
1h7b_A_5171h7b   A527536AAQHLDYFGVHHHH-SEEEEaaaababbbb
1hg8_A_351hg8   A3847AVSSCKNIVLHHHH-SEEEEaaaababbbx
1hiz_A_431hiz   A4958LKRHFNSIVAHHHH-SEEEEaaaababbbx
1i1w_A_321i1w   A3645IQANFGQVTPHHHH-SEEEEaaaababbbx
1i4n_A_641i4n   A7180YDELADAISIHHHH-SEEEEaaaababbbb
1iib_A_441iib   A4756KGQNADVVLLHHTT-SEEEEaaaaxabbbb
1im4_A_781im4   A92101LNKHADKIEVHHTT-SEEEEaaaababbbx
1itx_A_2641itx   A267276IAAIVDWINIHHHHSSEEEEaaaaxabbxx
1j79_A_221j79   A3241TSEIYGRAIVHHTT-SEEEEaaaaxabbxx
1jbw_A_3481jbw   A355364LTAAFSTVYLHHHH-SEEEEaaaababbbb
1k1e_A_1121k1e   A114123AFAACGTSFAHHHHSSEEEEaaaaxabbbb
1knq_A_591knq   A7685MQRTNKVSLIHHHH-SEEEEaaaababbbb
1lg2_A_1971lg2   A200209IAQNLDFVNLHHHH-SEEEEaaaaxabbxx
1liu_A_3231liu   A326335ILEVSDGIMVHHHHSSEEEEaaaababbbx
1ll2_A_451ll2   A5160LEIVFDEVITHHHH-SEEEEaaaababbbb
1lzj_A_1981lzj   A200209FLSEVDYLVCHHHH-SEEEEaaaababbbb
1m4i_A_951m4i   A107116MRGAYQLGALHHHH-SEEEEaaaababxbb
1mdw_A_3281mdw   A331340FLRHYSRLEIHHHH--EEEEaaaaxabbbb
1mx3_A_2231mx3   A226235LLFHSDCVTLHHHH-SEEEEaaaaxabbbx
1n2s_A_1621n2s   A169178LAKERQTLSVHHHH-SEEEEaaaababbbb
1nqk_A_1811nqk   A187196AAEQVDLYLTHHHH-SEEEEaaaaxabxxb
1o60_A_1021o60   A105114VADVVDIIQLHHTT-SEEEEaaaaxabbbx
1o6b_A_161o6b   A2534GAHIFEQVYVHHHHSSEEEEaaaaxabbbx
1o7q_A_2141o7q   A214223IQHEVDFLFCHHHH-SEEEEaaaababbbb
1ojr_A_1911ojr   A200209EMQKHSLVLWHHTT-SEEEEaaaababbxb
1oth_A_1241oth   A131140LSSMADAVLAHHHH-SEEEEaaaababbbb
1qam_A_431qam   A4857LVQRCNFVTAHHHHSSEEEEaaaababbbx
1qjc_A_161qjc   A2534ATQMFDHVILHHTTSSEEEEaaaababbxx
1tmo_*_1731tmo   -176185ILEHSDTIVLHHHH-SEEEEaaaaxabbxx
1ual_A_1201ual   A123132IQTEIDEEWSHHHH-SEEEEaaaaxabbbb
2cev_A_2032cev   A214223LKERTDGVHLHHTT-SEEEEaaaNbabbxb
2dnj_A_192dnj   A2837IVRRYDIVLIHHHT-SEEEEaaaababbxb
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1aqf_E_2791aqf   E     PEQL-PHOSPHOLACTATE M - 290
1aqf_E_2791aqf   E     PEQL-PHOSPHOLACTATE V - 291
1aqf_E_2791aqf   E     PEQL-PHOSPHOLACTATE A - 292
1ccw_B_1271ccw   B     TARD(-)-TARTARIC ACID R - 149
1coz_A_151coz   A     CTPCYTIDINE-5'-TRIPHOSPHATE G - 16
1coz_A_151coz   A     CTPCYTIDINE-5'-TRIPHOSPHATE H - 17
1coz_A_151coz   A     CTPCYTIDINE-5'-TRIPHOSPHATE L - 20
1coz_A_151coz   A     CTPCYTIDINE-5'-TRIPHOSPHATE R - 23
1dmr_*_1711dmr   *     PGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE W - 184
1dnl_A_881dnl   A     FMNFLAVIN MONONUCLEOTIDE R - 88
1dnl_A_881dnl   A     FMNFLAVIN MONONUCLEOTIDE K - 89
1dnl_A_881dnl   A     FMNFLAVIN MONONUCLEOTIDE A - 90
1dnl_A_881dnl   A     FMNFLAVIN MONONUCLEOTIDE Q - 92
1dnl_A_881dnl   A     MSESELENOMETHIONINE S - 100
1dnl_A_881dnl   A     MSESELENOMETHIONINE L - 101
1e6c_A_1261e6c   A     MPD2-METHYL-2,4-PENTANEDIOL I - 128
1e6c_A_1261e6c   A     MPD2-METHYL-2,4-PENTANEDIOL A - 129
1e6c_A_1261e6c   A     MPD2-METHYL-2,4-PENTANEDIOL E - 130
1e6c_A_1261e6c   A     MPD2-METHYL-2,4-PENTANEDIOL M - 132
1e6c_A_1261e6c   A     MPD2-METHYL-2,4-PENTANEDIOL E - 133
1e6c_A_1261e6c   A     MPD2-METHYL-2,4-PENTANEDIOL V - 135
1e6c_A_1261e6c   A     MPD2-METHYL-2,4-PENTANEDIOL L - 136
1e6c_A_1261e6c   A     MPD2-METHYL-2,4-PENTANEDIOL R - 139
1e6c_A_1261e6c   A     MPD2-METHYL-2,4-PENTANEDIOL Y - 143
1e8c_A_3991e8c   A     MSESELENOMETHIONINE A - 399
1e8c_A_3991e8c   A     MSESELENOMETHIONINE I - 400
1e8c_A_3991e8c   A     MSESELENOMETHIONINE A - 401
1e8c_A_3991e8c   A     MSESELENOMETHIONINE E - 402
1e8c_A_3991e8c   A     MSESELENOMETHIONINE A - 408
1e8c_A_3991e8c   A     MSESELENOMETHIONINE V - 409
1e8c_A_3991e8c   A     MSESELENOMETHIONINE V - 410
1esw_A_2741esw   A     ACRACARBOSE R - 291
1esw_A_2741esw   A     ACRACARBOSE D - 293
1esw_A_2741esw   A     EDO1,2-ETHANEDIOL D - 293
1eu1_A_1711eu1   A     CSD3-SULFINOALANINE M - 181
1eu1_A_1711eu1   A     CSD3-SULFINOALANINE V - 182
1eu1_A_1711eu1   A     CSD3-SULFINOALANINE F - 183
1eu1_A_1711eu1   A     CSD3-SULFINOALANINE W - 184
1eu1_A_1711eu1   A     MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE W - 184
1f07_A_1551f07   A     MPD2-METHYL-2,4-PENTANEDIOL P - 155
1f07_A_1551f07   A     MPD2-METHYL-2,4-PENTANEDIOL L - 158
1f07_A_1551f07   A     MPD2-METHYL-2,4-PENTANEDIOL I - 170
1f5a_A_3671f5a   A     MSESELENOMETHIONINE F - 368
1f5a_A_3671f5a   A     MSESELENOMETHIONINE Y - 374
1f5a_A_3671f5a   A     MSESELENOMETHIONINE I - 375
1f5a_A_3671f5a   A     MSESELENOMETHIONINE V - 376
1fxp_A_10881fxp   A     PO4PHOSPHATE ION Q - 1099
1fxp_A_10881fxp   A     PO4PHOSPHATE ION I - 1100
1g8k_A_6851g8k   A     MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE W - 697
1g8k_A_6851g8k   A     MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE N - 699
1g8k_A_6851g8k   A     MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE N - 700
1g8k_A_6851g8k   A     MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE G - 701
1gup_A_1241gup   A     GDUGALACTOSE-URIDINE-5'-DIPHOSPHATE F - 151
1gup_A_1241gup   A     GDUGALACTOSE-URIDINE-5'-DIPHOSPHATE E - 152
1gup_A_1241gup   A     GDUGALACTOSE-URIDINE-5'-DIPHOSPHATE N - 153
1gy9_A_291gy9   A     FEFE (III) ION E - 33
1gy9_A_291gy9   A     FEFE (III) ION Y - 36
1gy9_A_291gy9   A     FEFE (III) ION H - 37
1i1w_A_321i1w   A     PCAPYROGLUTAMIC ACID A - 33
1i1w_A_321i1w   A     PCAPYROGLUTAMIC ACID A - 34
1i1w_A_321i1w   A     PCAPYROGLUTAMIC ACID I - 35
1i1w_A_321i1w   A     PCAPYROGLUTAMIC ACID I - 36
1i1w_A_321i1w   A     GOLGLYCEROL I - 36
1i1w_A_321i1w   A     PCAPYROGLUTAMIC ACID Q - 37
1i1w_A_321i1w   A     GOLGLYCEROL Q - 37
1i1w_A_321i1w   A     PCAPYROGLUTAMIC ACID A - 38
1i1w_A_321i1w   A     GOLGLYCEROL A - 38
1i1w_A_321i1w   A     PCAPYROGLUTAMIC ACID N - 39
1i1w_A_321i1w   A     GOLGLYCEROL N - 39
1i1w_A_321i1w   A     GOLGLYCEROL F - 40
1i1w_A_321i1w   A     GOLGLYCEROL G - 41
1itx_A_2641itx   A     GOLGLYCEROL N - 275
1itx_A_2641itx   A     GOLGLYCEROL I - 276
1k1e_A_1121k1e   A     HGMERCURY (II) ION P - 113
1k1e_A_1121k1e   A     HGMERCURY (II) ION A - 114
1k1e_A_1121k1e   A     HGMERCURY (II) ION F - 115
1k1e_A_1121k1e   A     HGMERCURY (II) ION A - 117
1k1e_A_1121k1e   A     HGMERCURY (II) ION C - 118
1lg2_A_1971lg2   A     EDO1,2-ETHANEDIOL N - 208
1lg2_A_1971lg2   A     EDO1,2-ETHANEDIOL M - 210
1liu_A_3231liu   A     PGA2-PHOSPHOGLYCOLIC ACID M - 334
1liu_A_3231liu   A     PGA2-PHOSPHOGLYCOLIC ACID V - 335
1liu_A_3231liu   A     PGA2-PHOSPHOGLYCOLIC ACID A - 336
1liu_A_3231liu   A     MNMANGANESE (II) ION A - 336
1lzj_A_1981lzj   A     HGMERCURY (II) ION F - 200
1lzj_A_1981lzj   A     HGMERCURY (II) ION L - 207
1lzj_A_1981lzj   A     HGMERCURY (II) ION V - 208
1lzj_A_1981lzj   A     HGMERCURY (II) ION C - 209
1lzj_A_1981lzj   A     HGMERCURY (II) ION V - 210
1lzj_A_1981lzj   A     UDPURIDINE-5'-DIPHOSPHATE V - 210
1m4i_A_951m4i   A     COACOENZYME A L - 95
1m4i_A_951m4i   A     COACOENZYME A V - 96
1m4i_A_951m4i   A     COACOENZYME A S - 97
1m4i_A_951m4i   A     COACOENZYME A L - 99
1m4i_A_951m4i   A     COACOENZYME A L - 116
1m4i_A_951m4i   A     KANKANAMYCIN A L - 116
1m4i_A_951m4i   A     COACOENZYME A S - 117
1m4i_A_951m4i   A     KANKANAMYCIN A S - 117
1mx3_A_2231mx3   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE L - 235
1o60_A_1021o60   A     MSESELENOMETHIONINE C - 102
1o60_A_1021o60   A     MSESELENOMETHIONINE P - 104
1o60_A_1021o60   A     MSESELENOMETHIONINE V - 105
1o60_A_1021o60   A     MSESELENOMETHIONINE I - 112
1o60_A_1021o60   A     MSESELENOMETHIONINE Q - 113
1o60_A_1021o60   A     MSESELENOMETHIONINE L - 114
1o6b_A_161o6b   A     ADPADENOSINE-5'-DIPHOSPHATE Y - 16
1o6b_A_161o6b   A     ADPADENOSINE-5'-DIPHOSPHATE G - 17
1o6b_A_161o6b   A     PO4PHOSPHATE ION H - 18
1o6b_A_161o6b   A     ADPADENOSINE-5'-DIPHOSPHATE H - 18
1o6b_A_161o6b   A     MSESELENOMETHIONINE D - 20
1o6b_A_161o6b   A     ADPADENOSINE-5'-DIPHOSPHATE D - 20
1o6b_A_161o6b   A     MSESELENOMETHIONINE I - 21
1o6b_A_161o6b   A     ADPADENOSINE-5'-DIPHOSPHATE I - 21
1o6b_A_161o6b   A     MSESELENOMETHIONINE I - 22
1o6b_A_161o6b   A     MSESELENOMETHIONINE R - 24
1o6b_A_161o6b   A     ADPADENOSINE-5'-DIPHOSPHATE R - 24
1o6b_A_161o6b   A     MSESELENOMETHIONINE G - 25
1o7q_A_2141o7q   A     UDPURIDINE-5'-DIPHOSPHATE M - 224
1ojr_A_1911ojr   A     ZNZINC ION W - 209
1ojr_A_1911ojr   A     PO4PHOSPHATE ION W - 209
1ojr_A_1911ojr   A     2HADIHYDROXYACETONE W - 209
1oth_A_1241oth   A     PAON-(PHOSPHONOACETYL)-L-ORNITHINE R - 141
1tmo_*_1731tmo   *     2MDGUANYLATE-O'-PHOSPHORIC ACID MONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,5,6,7,8A,9,10,10A-OCTAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL) ESTER W - 186
1ual_A_1201ual   A     SAHS-ADENOSYL-L-HOMOCYSTEINE W - 131
1ual_A_1201ual   A     SAHS-ADENOSYL-L-HOMOCYSTEINE S - 132
2cev_A_2032cev   A     MNMANGANESE (II) ION D - 226
2dnj_A_192dnj   A     NAGN-ACETYL-D-GLUCOSAMINE A - 19
2dnj_A_192dnj   A     NAGN-ACETYL-D-GLUCOSAMINE T - 20
2dnj_A_192dnj   A     NAGN-ACETYL-D-GLUCOSAMINE L - 21
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1gy9_A_291gy9   A AC2FE BINDING SITE FOR CHAIN AE - 33
1gy9_A_291gy9   A AC2FE BINDING SITE FOR CHAIN AH - 37
2cev_A_2032cev   A MNAMN 301 BOUND TO HIS 99 ND1, ASP 122 OD2, ASP 126 OD2, ASP 226 OD2, A BRIDGING WATER HOH1 AND A TERMINAL WATER HOH MN 302 BOUND TO HIS 124 ND1, ASP 122 OD1, ASP 226 OD2, ASP 228 OD1, ASP 228 OD2 AND THE BRIDGING WATER HOH1D - 226

Clusters included in this Subclass
CLUSTER: HE.1.28
CLUSTER: HE.1.5
CLUSTER: HE.2.10
CLUSTER: HE.3.13
CLUSTER: HE.3.98
CLUSTER: HE.4.41
CLUSTER: HE.5.44