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Information on SUBCLASS 5.1.1
Subclass Accession number: 7437
Subclass: 5.1.1 PSSM
Type: EH beta-alpha
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 45

Average sequence ID (%) : 12.6 +/- 17.1
Average RMSD (Å) : 0.902 +/- 0.218

Consensus geometry
d (Å): 13 delta (°): 45-90 theta (°): 135-180 rho (°): 315-360
Consensus Sequence: XhXXXXpXp
(φψ)-conformation: bbpaappaa
Pattern: xxxx[afgilpvwy]xx[adegkqrst]x[adnpstv]x[adegkqs][adeknqrst][afgiklmtv]
Conservation:-1.000-1.383-0.021-1.4420.431-0.784-0.6260.4390.0370.982-1.1861.1601.0571.337
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1bgv_A_881bgv   A90103GGLRFAPSVNLSIMEEEEE-TT--HHHHexbbbbaapbaaaa
1bvu_A_711bvu   A7182..IRWHPEETLSTV..EEEETT--HHHH..bbbbaaxbaaaa
1cf2_O_1041cf2   O104116.KAIFQGGEKHEDI.EEEE-TTS-HHHH.xbbbbaaxxaaaa
1cxv_A_961cxv   A100113RIVNYTPDMSHSEVEE----TTS-HHHHbxabbxaabxaaaa
1d7k_B_121d7k   B1223..HFLDEGFTAKDI..EE--TT--HHHH..bpxxaabxaaaa
1dii_A_1251dii   A125137.YALVEPGVTFGQM.EEEE-TT--HHHH.bbbbbaaxxaaaa
1e8g_A_1391e8g   A139151.YCVVEPGVTYHDL.EEEE-TT-BHHHH.bbbbxaaxxaaaa
1euz_A_681euz   A7083GGIRWHPAETLSTVEEEEE-TT--HHHHexbxbbaapbaaaa
1f0x_A_1151f0x   A115127.QVLAYPGTTLYSL.EEEE-TT-BHHHH.bbbbbaaxxaaaa
1f5a_A_1141f5a   A116129ALCVAPRHVDRSDFEEEEE-TT--HHHHbbxbbxaabxaaaa
1fbl_*_1131fbl   -117130RIENYTPDLSREDVEE----TTS-HHHHbxabbxaabpaaaa
1fmt_A_1501fmt   A154167LSCPITAEDTSGTLEEEE--TT--HHHHbbbxxxaaxbaaaa
1gkd_A_1201gkd   A124137WIQNYSEDLPRAVIEE----SSS-HHHHbxabbxaabxaaaa
1gtm_A_711gtm   A7182..IRWHPEETLSTV..EEE-TT--HHHH..bxbbaapbaaaa
1gve_A_1031gve   A107120YLHFPDHGTPIEETEE-S--TTS-HHHHbxabxbaabpaaaa
1hfc_*_1131hfc   -117130RIENYTPDLPRADVEE----TTS-HHHHbxabbxaabxaaaa
1hn0_A_8711hn0   A873886YEYMVFLDATPEKMEEEEEETT--HHHHbbbbbbaaxbaaaa
1hv5_A_1131hv5   A117130RILRFPWQLVREQVEE-S--TTS-HHHHbxabbxaabxaaaa
1hwx_A_891hwx   A91104GGIRYSTDVSVDEVEEEEE-TT--HHHHexbxbbaaxbaaaa
1hy7_A_961hy7   A100113RIVNYTPDLPKDAVEE----TTS-HHHHbxabbxaabwaaaa
1i1q_A_4771i1q   A482495AGAGIVLDSVPQSEEE--B-TT--HHHHbbbxbbaaxbaaaa
1i76_A_921i76   A96109RIRNYTPQLSEAEVEE----TTS-HHHHbxabbbaabxaaaa
1i7q_A_4771i7q   A482495AGAGVVQDSIPEREEE--B-TT--HHHHbbbxbbaaxbaaaa
1j0x_O_261j0x   O2740VVAINDPFIDLHYMEEEEE-SSS-HHHHxabbbbaabxaaaa
1j93_A_2691j93   A269281.VVSLDWTVDMADG.EEE--TTS-HHHH.bbxxxaabxaaaa
1jcl_A_151jcl   A1629DLTTLNDDDTDEKVEEE---TT--HHHHxxbbbbaaxbaaaa
1jk3_A_1131jk3   A117130RINNYTPDMNREDVEE-S--TTS-HHHHbxabbxaabxaaaa
1jkx_A_1481jkx   A152165AKVPVFAGDSEDDIEEEE--TT--HHHHbbbxbbaapxaaaa
1jqb_A_11341jqb   A11341145..AILPKDMPLENA..EE--TTS-HHHH..bxxpaaxpaaaa
1k1x_A_4871k1x   A489502QDHFIKPEETLDNYEEEEE-TT--HHHHbxbbbxaaxbaaaa
1l6j_A_1201l6j   A124137WIQNYSEDLPRAVIEE----TTS-HHHHbxabbxaabxaaaa
1luc_A_1911luc   A191201...ILSWIINTHEK...EE-SSS-HHHH...bxxaabxaaaa
1mdb_A_1011mdb   A101114LPVFALPSHRSSEIEEEE--TT--HHHHbxbxxbaaxbaaaa
1mio_A_3611mio   A362375SLVAGFEFAHRDDYEEEEEESS--HHHHxabbbbaaxbaaaa
1mmq_*_1131mmq   -117130RIVSYTRDLPHITVEE----TTS-HHHHbxabbxaabwaaaa
1p0k_A_1191p0k   A119132IFANLGSEATAAQAEEEEEETT--HHHHbbxbbxaapxaaaa
1qdl_A_3041qdl   A311324VIGTLKKKYNALNVEEEEB-TT--HHHHbbbbxxaabbaaaa
1qdl_A_3851qdl   A390403AGAGIVYDSNPESEEEEEE-TT--HHHHbbbxxbaaxxaaaa
1qib_A_961qib   A100113RIIGYTPDLDPETVEE----TTS-HHHHbxabbbaabxaaaa
1qmh_A_2471qmh   A250263FFVVGEKRVSAEVVEEEE--TT--HHHHbbbxxxaabxaaaa
1qor_A_1061qor   A106118.AAILPAAISFEQA.EEE--TTS-HHHH.bbxxxaabxaaaa
1r3s_A_2791r3s   A279291.VVGLDWTVAPKKA.EEE--TTS-HHHH.bbxbxaaxxaaaa
1xyz_A_7491xyz   A755768IDIRIPQSENPATAEEEEEETTS-HHHHpbbxbpaaxxaaaa
1ykf_A_1341ykf   A134145..AHLPKEIPLEAA..EE--TTS-HHHH..bxxxaaxxaaaa
2tmg_A_712tmg   A7182..IRYHPDVTLDEV..EEEESS--HHHH..bbbbaapbaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1bgv_A_881bgv   A     GLUGLUTAMIC ACID K - 89
1bgv_A_881bgv   A     GLUGLUTAMIC ACID G - 90
1bgv_A_881bgv   A     GLUGLUTAMIC ACID G - 91
1bgv_A_881bgv   A     GLUGLUTAMIC ACID L - 92
1bgv_A_881bgv   A     GLUGLUTAMIC ACID Q - 110
1bgv_A_881bgv   A     GLUGLUTAMIC ACID K - 113
1bgv_A_881bgv   A     GLUGLUTAMIC ACID D - 114
1cf2_O_1041cf2   O     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Q - 108
1cf2_O_1041cf2   O     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 109
1cf2_O_1041cf2   O     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 110
1cf2_O_1041cf2   O     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE E - 111
1dii_A_1251dii   A     FADFLAVIN-ADENINE DINUCLEOTIDE P - 130
1dii_A_1251dii   A     FADFLAVIN-ADENINE DINUCLEOTIDE F - 134
1e8g_A_1391e8g   A     FADFLAVIN-ADENINE DINUCLEOTIDE P - 144
1e8g_A_1391e8g   A     FADFLAVIN-ADENINE DINUCLEOTIDE Y - 148
1f0x_A_1151f0x   A     FADFLAVIN-ADENINE DINUCLEOTIDE P - 120
1f5a_A_1141f5a   A     MNMANGANESE (II) ION I - 114
1f5a_A_1141f5a   A     MNMANGANESE (II) ION D - 115
1f5a_A_1141f5a   A     3AT3'-DEOXYADENOSINE-5'-TRIPHOSPHATE D - 115
1f5a_A_1141f5a   A     3POTRIPHOSPATE D - 115
1fbl_*_1131fbl   *     CACALCIUM ION T - 122
1fbl_*_1131fbl   *     CACALCIUM ION P - 123
1fbl_*_1131fbl   *     CACALCIUM ION D - 124
1gkd_A_1201gkd   A     CACALCIUM ION S - 129
1gkd_A_1201gkd   A     CACALCIUM ION E - 130
1gkd_A_1201gkd   A     CACALCIUM ION D - 131
1gkd_A_1201gkd   A     CACALCIUM ION V - 136
1gkd_A_1201gkd   A     CACALCIUM ION D - 139
1gkd_A_1201gkd   A     CACALCIUM ION R - 143
1gve_A_1031gve   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE H - 109
1gve_A_1031gve   A     CITCITRIC ACID H - 109
1gve_A_1031gve   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE F - 110
1gve_A_1031gve   A     CITCITRIC ACID F - 110
1gve_A_1031gve   A     GOLGLYCEROL D - 112
1gve_A_1031gve   A     GOLGLYCEROL H - 113
1gve_A_1031gve   A     GOLGLYCEROL G - 114
1gve_A_1031gve   A     GOLGLYCEROL T - 115
1gve_A_1031gve   A     GOLGLYCEROL I - 117
1hv5_A_1131hv5   A     CPS3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE L - 114
1hwx_A_891hwx   A     GLUGLUTAMIC ACID K - 90
1hwx_A_891hwx   A     GLUGLUTAMIC ACID G - 92
1hwx_A_891hwx   A     GLUGLUTAMIC ACID I - 93
1hwx_A_891hwx   A     NAI1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE R - 94
1hwx_A_891hwx   A     NAI1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE L - 107
1hwx_A_891hwx   A     GLUGLUTAMIC ACID M - 111
1hwx_A_891hwx   A     NAI1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE T - 112
1hwx_A_891hwx   A     GLUGLUTAMIC ACID K - 114
1hwx_A_891hwx   A     NAI1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE K - 114
1hwx_A_891hwx   A     NAI1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE C - 115
1hwx_A_891hwx   A     NAI1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE A - 116
1hy7_A_961hy7   A     CACALCIUM ION R - 100
1hy7_A_961hy7   A     CACALCIUM ION T - 105
1hy7_A_961hy7   A     CACALCIUM ION P - 106
1hy7_A_961hy7   A     CACALCIUM ION D - 107
1i7q_A_4771i7q   A     PYRPYRUVIC ACID Q - 481
1i7q_A_4771i7q   A     PYRPYRUVIC ACID A - 482
1i7q_A_4771i7q   A     BEZBENZOIC ACID G - 483
1i7q_A_4771i7q   A     PYRPYRUVIC ACID G - 483
1i7q_A_4771i7q   A     MGMAGNESIUM ION A - 484
1i7q_A_4771i7q   A     BEZBENZOIC ACID A - 484
1i7q_A_4771i7q   A     PYRPYRUVIC ACID A - 484
1i7q_A_4771i7q   A     MGMAGNESIUM ION G - 485
1i7q_A_4771i7q   A     BEZBENZOIC ACID G - 485
1i7q_A_4771i7q   A     PYRPYRUVIC ACID G - 485
1i7q_A_4771i7q   A     MGMAGNESIUM ION E - 495
1i7q_A_4771i7q   A     BEZBENZOIC ACID E - 495
1i7q_A_4771i7q   A     MGMAGNESIUM ION E - 498
1i7q_A_4771i7q   A     BEZBENZOIC ACID E - 498
1i7q_A_4771i7q   A     MGMAGNESIUM ION K - 502
1i7q_A_4771i7q   A     BEZBENZOIC ACID K - 502
1i7q_A_4771i7q   A     PYRPYRUVIC ACID K - 502
1jcl_A_151jcl   A     HPD1-HYDROXY-PENTANE-3,4-DIOL-5-PHOSPHATE D - 16
1jcl_A_151jcl   A     HPD1-HYDROXY-PENTANE-3,4-DIOL-5-PHOSPHATE T - 18
1jcl_A_151jcl   A     HPD1-HYDROXY-PENTANE-3,4-DIOL-5-PHOSPHATE L - 20
1jkx_A_1481jkx   A     138N-[5'-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY -QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE T - 166
1jkx_A_1481jkx   A     138N-[5'-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY -QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE V - 169
1jkx_A_1481jkx   A     138N-[5'-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY -QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE Q - 170
1jkx_A_1481jkx   A     138N-[5'-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY -QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE E - 173
1jkx_A_1481jkx   A     138N-[5'-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY -QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE H - 174
1mio_A_3611mio   A     CFMFE-MO-S CLUSTER F - 367
1mio_A_3611mio   A     CACALCIUM ION E - 368
1mio_A_3611mio   A     HCA3-HYDROXY-3-CARBOXY-ADIPIC ACID E - 368
1mio_A_3611mio   A     CFMFE-MO-S CLUSTER E - 368
1mio_A_3611mio   A     CACALCIUM ION F - 369
1mio_A_3611mio   A     HCA3-HYDROXY-3-CARBOXY-ADIPIC ACID F - 369
1mio_A_3611mio   A     CFMFE-MO-S CLUSTER F - 369
1qor_A_1061qor   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE L - 123
1qor_A_1061qor   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE K - 124
1qor_A_1061qor   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE T - 127
1qor_A_1061qor   A     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Y - 130
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1gve_A_1031gve   A BC5CIT BINDING SITE FOR CHAIN AH - 109
1gve_A_1031gve   A AC7GOL BINDING SITE FOR CHAIN AH - 113

Clusters included in this Subclass
CLUSTER: EH.4.22
CLUSTER: EH.5.14
CLUSTER: EH.5.28
CLUSTER: EH.6.151
CLUSTER: EH.6.20
CLUSTER: EH.6.24
CLUSTER: EH.7.1