Extending signalling pathways with protein-interaction networks. Application to apoptosis.
Extending signalling pathways with protein-interaction networks. Application to apoptosis.
Joan Planas-Iglesias, Emre Guney, Javier Garcia-Garcia, Kevin A. Robertson, Sobia Raza, Tom C. Freeman, Peter Ghazal and Baldo Oliva.
OMICS. 2012 May;16(5):245-56. Epub 2012 Mar 2. (PMID: 22385281)
Joan Planas-Iglesias, Emre Guney, Javier Garcia-Garcia, Kevin A. Robertson, Sobia Raza, Tom C. Freeman, Peter Ghazal and Baldo Oliva.
OMICS. 2012 May;16(5):245-56. Epub 2012 Mar 2. (PMID: 22385281)
Further results for "Extending signalling pathways with protein-interaction networks. Application to apoptosis."
Here we present all the numerical results obtained in this study. Details on each scoring method, their combinations, the best combination for each network, and the protein candidates obtained are provided here. The links in the table lead to the information for each of the apoptosis-related networks we analyzed.
Networks analyzed
Network name | Number of nodes |
---|---|
Experimental | 1014 |
STRING+ | 2868 |
Experimental expansion | 25207 |
STRING+ expansion | 33125 |
Known functions of proteins predicted to be involved in apoptotisby the scoring methods presented in the paper
273 new protein candidates obtained from the best combinations of ALD, iALD, FF, and SC. These candiates are unique proteins not present in any validation set that were yelded as predictions by the best combination of scoring methods from each analyzed apoptosis-related network. The link on the total number of new candidates leads to the description of the particular protein candidates.
Annotated function | Number of candidates |
---|---|
automated transcript | 159 |
annotated by orthology | 14 |
interacts with nucleic acid | 28 |
signaling pathways | 37 |
folding related | 3 |
other | 32 |
Total | 273 |