Extending signalling pathways with protein-interaction networks. Application to apoptosis.
Extending signalling pathways with protein-interaction networks. Application to apoptosis.
Joan Planas-Iglesias, Emre Guney, Javier Garcia-Garcia, Kevin A. Robertson, Sobia Raza, Tom C. Freeman, Peter Ghazal and Baldo Oliva.
OMICS. 2012 May;16(5):245-56. Epub 2012 Mar 2. (PMID: 22385281)
Joan Planas-Iglesias, Emre Guney, Javier Garcia-Garcia, Kevin A. Robertson, Sobia Raza, Tom C. Freeman, Peter Ghazal and Baldo Oliva.
OMICS. 2012 May;16(5):245-56. Epub 2012 Mar 2. (PMID: 22385281)
Supplementary materials for "Extending signalling pathways with protein-interaction networks. Application to apoptosis."
Supplementary table 7
Table S7. New apoptosis candidates and their potential interaction with seed proteins. Proteins predicted to be new members of the apoptosis pathways are shown in the first column (Candidates). The second column (Interacting seed proteins) shows the potential seed proteins interactors for each predicted candidate.
| Candidates | Interacting seed proteins |
|---|---|
| KS6A1_HUMAN | IKBA_HUMAN |
| Q7Z7F1_HUMAN | TNR1A_HUMAN |
| CAC1H_HUMAN | CASP8_HUMAN, DAXX_HUMAN, CASPA_HUMAN, TNR6_HUMAN, TNF10_HUMAN, TNR1A_HUMAN |
| HSP7C_HUMAN | CYC_HUMAN, TNR1A_HUMAN |
| CH60_HUMAN | CASP6_HUMAN, LAMA_HUMAN, ACINU_HUMAN, BAK_HUMAN, CASP3_HUMAN |
| CIKS_HUMAN | IKKB_HUMAN, IKKA_HUMAN, TRAF2_HUMAN |
| Q96EK7_HUMAN | TRAF2_HUMAN |
| PML_HUMAN | DAXX_HUMAN, P53_HUMAN |
| Q5JTM4_HUMAN | TRAF2_HUMAN |
| Q9BUZ3_HUMAN | TRAF2_HUMAN |
| TNR9_HUMAN | TRAF2_HUMAN, TNR1A_HUMAN |
| Q96AW0_HUMAN | TRAF2_HUMAN |
| NF2L2_HUMAN | CASP1_HUMAN, CASP3_HUMAN |
| NTHL1_HUMAN | P53_HUMAN |
| RIR2_HUMAN | P53_HUMAN |
| Q53GN5_HUMAN | TRAF2_HUMAN |
| Q12844_HUMAN | P53_HUMAN, BCL2_HUMAN, E2AK2_HUMAN, BCLX_HUMAN |
| NUCL_HUMAN | P53_HUMAN, PARP1_HUMAN |
| PIAS1_HUMAN | P53_HUMAN |
| Q53QD8_HUMAN | BCLX_HUMAN |
| TAOK3_HUMAN | TRAF2_HUMAN |
| ERCC3_HUMAN | P53_HUMAN |
| Q5T7S2_HUMAN | DAXX_HUMAN, IKBA_HUMAN, BIRC4_HUMAN |
| Q5JSD2_HUMAN | CYC_HUMAN, BAK_HUMAN |
| M4K5_HUMAN | TRAF2_HUMAN |
| Q8TAW9_HUMAN | CASP3_HUMAN |
| Q53TI5_HUMAN | TRAF2_HUMAN |
| B2L12_HUMAN | BCLX_HUMAN |
| PABP1_HUMAN | IF2A_HUMAN |
| SYQ_HUMAN | TRAF2_HUMAN |
| TBK1_HUMAN | IKKB_HUMAN, IKKA_HUMAN, TRAF2_HUMAN |
| 1433S_HUMAN | BAXC_HUMAN, BAXB_HUMAN, BAXD_HUMAN, BAXA_HUMAN, BAD_HUMAN |
| AKT2_HUMAN | IKKB_HUMAN, IKKA_HUMAN, BAD_HUMAN, IKBA_HUMAN |
| Q53BH6_HUMAN | CASP2_HUMAN |
| TNR8_HUMAN | TNR6_HUMAN, BCL2_HUMAN, TRAF2_HUMAN, TNR1A_HUMAN |
| Q8IZ48_HUMAN | TNR6_HUMAN, TRAF2_HUMAN |
| COMD1_HUMAN | IKBA_HUMAN, BIRC4_HUMAN |
| Q3SY13_HUMAN | BCLX_HUMAN |
| Q71T04_HUMAN | CASP2_HUMAN, BCLX_HUMAN, BID_HUMAN |
| Q53TC8_HUMAN | TRAF2_HUMAN |
| Q53SF9_HUMAN | TRAF2_HUMAN |
| VDAC2_HUMAN | CYC_HUMAN, BAK_HUMAN |
| Q7Z6Q2_HUMAN | IKKB_HUMAN, IKKA_HUMAN, TRAF2_HUMAN |
| Q99618_HUMAN | TNR6_HUMAN, TR10A_HUMAN, TRAF2_HUMAN, TNR1A_HUMAN |
| RB6I2_HUMAN | IKBA_HUMAN |
| Q6NW12_HUMAN | TRAF2_HUMAN |
| M3K1_HUMAN | IKBA_HUMAN, TRADD_HUMAN, TRAF2_HUMAN, CASP7_HUMAN, RIPK1_HUMAN, IKKB_HUMAN, IKKA_HUMAN, TNR1A_HUMAN |
| HIF1A_HUMAN | P53_HUMAN |
| Q16526_HUMAN | TRAF2_HUMAN |
| NCB5R_HUMAN | CYC_HUMAN |
| Q8TBA7_HUMAN | P53_HUMAN, TNR1A_HUMAN |
| Q5JTM3_HUMAN | TRAF2_HUMAN |
| Q96IS6_HUMAN | CYC_HUMAN, TNR1A_HUMAN |
| Q2TB79_HUMAN | P53_HUMAN |
| Q86SI0_HUMAN | P53_HUMAN |
| Q5SQL5_HUMAN | P53_HUMAN |
| PIN1_HUMAN | P53_HUMAN, BCL2_HUMAN, TNFA_HUMAN, TRAF2_HUMAN |
| TNR4_HUMAN | TRAF2_HUMAN, TNR1A_HUMAN |
| Q96IF6_HUMAN | TNR6_HUMAN, TRAF2_HUMAN |
| Q9BTG7_HUMAN | TRAF2_HUMAN |
| Q5SQL2_HUMAN | P53_HUMAN |
| Q5BKZ4_HUMAN | BCLX_HUMAN, TNR1A_HUMAN |
| DVL2_HUMAN | P53_HUMAN, TNFA_HUMAN, TRAF2_HUMAN |
| CABL2_HUMAN | P53_HUMAN, IF2A_HUMAN |
| TOP2A_HUMAN | DFFB_HUMAN, DFFA_HUMAN |
| ANXA5_HUMAN | CASP8_HUMAN, TNR6_HUMAN, BAXB_HUMAN, BAXD_HUMAN, CASP3_HUMAN, BAXA_HUMAN, BAXC_HUMAN, CASP9_HUMAN, BCL2_HUMAN, BCLX_HUMAN, TR10B_HUMAN, TNF10_HUMAN |
| KC1D_HUMAN | P53_HUMAN, IKKB_HUMAN |
| Q8N632_HUMAN | TRAF2_HUMAN |
| Q12845_HUMAN | P53_HUMAN, BCL2_HUMAN, E2AK2_HUMAN, BCLX_HUMAN |
| Q8N634_HUMAN | TRAF2_HUMAN, TNR1A_HUMAN |
| Q53QD5_HUMAN | CASP6_HUMAN, BAK_HUMAN, CASP3_HUMAN |
| TISB_HUMAN | P53_HUMAN |
| Q93046_HUMAN | P53_HUMAN |
| Q5JTE9_HUMAN | FADD_HUMAN |
| Q5TAV5_HUMAN | P53_HUMAN |
| Q96AW5_HUMAN | TRAF2_HUMAN |
| Q5R3A3_HUMAN | IKKB_HUMAN, IKKA_HUMAN, TRAF2_HUMAN |
| IRAK1_HUMAN | IKKA_HUMAN, FADD_HUMAN, E2AK2_HUMAN, IKKB_HUMAN, IKBA_HUMAN |
| Q6P2H9_HUMAN | TRAF2_HUMAN |
| HS90A_HUMAN | IKKB_HUMAN, IF2A_HUMAN, E2AK2_HUMAN, TNFA_HUMAN, RIPK1_HUMAN, P53_HUMAN, IKKA_HUMAN, TNR1A_HUMAN |
| Q96GK1_HUMAN | TRAF2_HUMAN |
| LAM1_HUMAN | CASP6_HUMAN, CASP2_HUMAN, CASP3_HUMAN, LAMA_HUMAN |
| PPRB_HUMAN | RIPK1_HUMAN, P53_HUMAN |
| Q69BM3_HUMAN | BCLX_HUMAN |
| PLK3_HUMAN | P53_HUMAN |
| FBW1B_HUMAN | IKBA_HUMAN |
| Q5T3J9_HUMAN | P53_HUMAN |
| CYB5_HUMAN | CYC_HUMAN |
| Q69BL8_HUMAN | BCLX_HUMAN |
| Q5SQL1_HUMAN | P53_HUMAN |
| PNPH_HUMAN | P53_HUMAN, E2AK2_HUMAN |
| CBP_HUMAN | DAXX_HUMAN, HTRA2_HUMAN, P53_HUMAN |
| Q7LG56_HUMAN | P53_HUMAN |
| Q6PI38_HUMAN | P53_HUMAN |
| Q8NFL2_HUMAN | P53_HUMAN, TRAF2_HUMAN |
| M3K3_HUMAN | RIPK1_HUMAN, IKKB_HUMAN, IKKA_HUMAN |
| Q4VXV4_HUMAN | P53_HUMAN |
| IF2B_HUMAN | P53_HUMAN, E2AK2_HUMAN, IF2A_HUMAN |
| DYL2_HUMAN | BIRC4_HUMAN |
| Q4VY19_HUMAN | BCL2_HUMAN, BID_HUMAN, BCLX_HUMAN, BAD_HUMAN |
| Q96SH0_HUMAN | P53_HUMAN |
| Q69BM2_HUMAN | BCLX_HUMAN |
| Q96RU3_HUMAN | TNFL6_HUMAN |
| Q69BM5_HUMAN | BCLX_HUMAN |
| Q9BQF7_HUMAN | TRAF2_HUMAN |
| TS101_HUMAN | P53_HUMAN |
| Q5VWK1_HUMAN | CYC_HUMAN, BAK_HUMAN |
| Q8IYN1_HUMAN | TRAF2_HUMAN |
| ROAA_HUMAN | IKBA_HUMAN |
| Q8N717_HUMAN | P53_HUMAN |
| Q6IAX4_HUMAN | BCLX_HUMAN |
| Q5JZA5_HUMAN | TRAF2_HUMAN, TNR1A_HUMAN |
| Q6Q322_HUMAN | TRAF2_HUMAN, TNR1A_HUMAN |
| Q8N1C6_HUMAN | P53_HUMAN |
| Q6IB40_HUMAN | CYC_HUMAN, BAK_HUMAN |
| P2AA_HUMAN | P53_HUMAN, HTRA2_HUMAN, BCL2_HUMAN |
| Q5VUI8_HUMAN | TRAF2_HUMAN |
| HMG2_HUMAN | DFFB_HUMAN, P53_HUMAN, DFFA_HUMAN |
| Q4VXV5_HUMAN | P53_HUMAN |
| RFX3_HUMAN | TRAF2_HUMAN |
| AP1_HUMAN | IKKA_HUMAN, IKBA_HUMAN |
| L1CAM_HUMAN | IKKA_HUMAN, FADD_HUMAN, E2AK2_HUMAN, IKKB_HUMAN, IKBA_HUMAN |
| MK01_HUMAN | CASP9_HUMAN, BCL2_HUMAN, BCLX_HUMAN, BAD_HUMAN, IKBA_HUMAN |
| Q5U007_HUMAN | TNR6_HUMAN, TRADD_HUMAN, TRAF2_HUMAN, BCL2_HUMAN, BCLX_HUMAN, TNR1A_HUMAN |
| Q12800_HUMAN | CASP8_HUMAN |
| Q96KX3_HUMAN | P53_HUMAN |
| CAN1_HUMAN | BID_HUMAN, IKBA_HUMAN |
| CYLD_HUMAN | IKKA_HUMAN, TRAF2_HUMAN |
| Q6Y4Q7_HUMAN | CASP7_HUMAN, TRAF2_HUMAN, TNR1A_HUMAN |
| ETS1_HUMAN | DAXX_HUMAN, IKBA_HUMAN |
| IPYR_HUMAN | P53_HUMAN, TR10B_HUMAN |
| Q7Z4M9_HUMAN | TR10B_HUMAN, TNR6_HUMAN, DBLOH_HUMAN, CASP2_HUMAN, BIRC4_HUMAN, BAXD_HUMAN, CASP7_HUMAN, CASP9_HUMAN, CYC_HUMAN, PDCD8_HUMAN, FADD_HUMAN, CASP8_HUMAN, APAF_HUMAN, BAXA_HUMAN, BCL2_HUMAN, BCLX_HUMAN, BAD_HUMAN, TR10A_HUMAN, TNF10_HUMAN, BID_HUMAN, BAXB_HUMAN, CASPA_HUMAN, CASP3_HUMAN, BAXC_HUMAN, BAK_HUMAN |
| Q9NS52_HUMAN | P53_HUMAN |
| TANK_HUMAN | IKKB_HUMAN, TRAF2_HUMAN |
| ADT1_HUMAN | BAXC_HUMAN, BAXB_HUMAN, BAXD_HUMAN, BAXA_HUMAN, IKBA_HUMAN |
| ZN205_HUMAN | TRAF2_HUMAN |
| Q6I9Y7_HUMAN | P53_HUMAN |
| MIZF_HUMAN | TRAF2_HUMAN |
| PARP3_HUMAN | PARP1_HUMAN |
| CCNH_HUMAN | P53_HUMAN |
| Q502Z6_HUMAN | IF2A_HUMAN |
| MYD88_HUMAN | FADD_HUMAN, IKKA_HUMAN |
| Q9BQ59_HUMAN | BCLX_HUMAN |
| AAPK2_HUMAN | E2AK2_HUMAN |
| HIPK1_HUMAN | DAXX_HUMAN, P53_HUMAN, E2AK2_HUMAN |
| Q9NYJ8_HUMAN | IKKA_HUMAN, E2AK2_HUMAN, BIRC4_HUMAN |
| IKBB_HUMAN | IKKB_HUMAN, IKKA_HUMAN, IKBA_HUMAN |
| ERCC2_HUMAN | P53_HUMAN |
| Q8IY86_HUMAN | CASP2_HUMAN, BCLX_HUMAN, BID_HUMAN |
| Q49AR7_HUMAN | P53_HUMAN, TRAF2_HUMAN |
| AP2A_HUMAN | P53_HUMAN |
| Q96G48_HUMAN | FADD_HUMAN |
| Q9NWA1_HUMAN | P53_HUMAN |
| TNR11_HUMAN | TRAF2_HUMAN |
| Q5T1L7_HUMAN | TRAF2_HUMAN, TNR1A_HUMAN |
| Q96SH1_HUMAN | P53_HUMAN |
| EP300_HUMAN | P53_HUMAN, RIPK1_HUMAN, HTRA2_HUMAN, BCL2_HUMAN |
| Q5ZEZ1_HUMAN | P53_HUMAN |
| Q5T9G8_HUMAN | P53_HUMAN |
| Q4ZFV6_HUMAN | BCLX_HUMAN |
| PPA5_HUMAN | TNF10_HUMAN |
| KLF4_HUMAN | P53_HUMAN |
| CRTAP_HUMAN | TR10B_HUMAN, CASP2_HUMAN, CASP3_HUMAN, CASP4_HUMAN |
| NRIP1_HUMAN | RIPK1_HUMAN, TRAF2_HUMAN |
| PERI_HUMAN | CASP8_HUMAN, CASP9_HUMAN |
| Q4ZG76_HUMAN | TRAF2_HUMAN |
| Q5JTF1_HUMAN | FADD_HUMAN |
| BCN1_HUMAN | BCL2_HUMAN, BCLX_HUMAN |
| ABCA1_HUMAN | IKKB_HUMAN, APAF_HUMAN, E2AK2_HUMAN, RIPK1_HUMAN, FADD_HUMAN, IKKA_HUMAN |
| K1C18_HUMAN | TRADD_HUMAN, CASP3_HUMAN |
| PSN2_HUMAN | BCLX_HUMAN |
| Q9BWK8_HUMAN | CYC_HUMAN, BAK_HUMAN |
| FLNA_HUMAN | TRAF2_HUMAN, IF2A_HUMAN, LAMA_HUMAN |
| Q5JTE7_HUMAN | FADD_HUMAN |
| AIOL_HUMAN | HTRA2_HUMAN, BCLX_HUMAN |
| DP13A_HUMAN | TRAF2_HUMAN |
| Q5SQT6_HUMAN | P53_HUMAN |
| Q9UML1_HUMAN | CYC_HUMAN |
| Q6FH51_HUMAN | BAD_HUMAN |
| Q5JSD1_HUMAN | CYC_HUMAN, BAK_HUMAN |
| Q96C41_HUMAN | BCL2_HUMAN, BCLX_HUMAN |
| 1433B_HUMAN | BCL2_HUMAN, BID_HUMAN, BCLX_HUMAN, BAD_HUMAN |
| M3K14_HUMAN | CASP8_HUMAN, E2AK2_HUMAN, TRADD_HUMAN, TRAF2_HUMAN, TNR1A_HUMAN, RIPK1_HUMAN, IKKB_HUMAN, IKKA_HUMAN, IKBA_HUMAN |
| Q7Z6Q3_HUMAN | IKKB_HUMAN, IKKA_HUMAN, TRAF2_HUMAN |
| M4K3_HUMAN | TRAF2_HUMAN |
| NEMO_HUMAN | RIPK1_HUMAN, IKKB_HUMAN, IKKA_HUMAN, TNR1A_HUMAN, IKBA_HUMAN |
| TOP2B_HUMAN | P53_HUMAN, PARP1_HUMAN, TNFA_HUMAN |
| Q69BL9_HUMAN | BCLX_HUMAN |
| Q69BL7_HUMAN | BCLX_HUMAN |
| Q5JTF0_HUMAN | FADD_HUMAN |
| Q53T51_HUMAN | TRAF2_HUMAN |
| CTNB1_HUMAN | CASP8_HUMAN, IKKB_HUMAN, IKKA_HUMAN, CASP3_HUMAN |
| Q3SYD7_HUMAN | P53_HUMAN |
| Q99638_HUMAN | BCL2_HUMAN, BCLX_HUMAN |
| Q5STV3_HUMAN | FAF1_HUMAN, TNF10_HUMAN, TR10B_HUMAN, TNFA_HUMAN, TNR1A_HUMAN |
| NEO1_HUMAN | CASP3_HUMAN |
| Q5CAQ7_HUMAN | P53_HUMAN, TNR1A_HUMAN |
| TP4AP_HUMAN | TRADD_HUMAN, TRAF2_HUMAN, RIPK1_HUMAN, IKKB_HUMAN, IKKA_HUMAN, TNR1A_HUMAN |
| Q96H53_HUMAN | CYC_HUMAN, TNR1A_HUMAN |
| Q9ULC9_HUMAN | FADD_HUMAN |
| Q96HX7_HUMAN | P53_HUMAN, TNR1A_HUMAN |
| CATG_HUMAN | CASP7_HUMAN, HTRA2_HUMAN |
| Q6LD16_HUMAN | P53_HUMAN |
| MPRI_HUMAN | TNR6_HUMAN, TNR1A_HUMAN |
| Q69BL6_HUMAN | BCLX_HUMAN |
| Q5VWK3_HUMAN | CYC_HUMAN, BAK_HUMAN |
| Q5T1L8_HUMAN | TRAF2_HUMAN, TNR1A_HUMAN |
| TNR17_HUMAN | TNF10_HUMAN, TNFA_HUMAN, TRAF2_HUMAN, BIRC4_HUMAN |
| IMA2_HUMAN | P53_HUMAN, ACINU_HUMAN, LAMA_HUMAN |
| NALP4_HUMAN | IKKA_HUMAN |
| Q12843_HUMAN | P53_HUMAN, BCL2_HUMAN, E2AK2_HUMAN, BCLX_HUMAN |
| Q5CAQ6_HUMAN | P53_HUMAN, TNR1A_HUMAN |
| Q69BM1_HUMAN | BCLX_HUMAN |
| Q8N574_HUMAN | BCLX_HUMAN |
| ANTR1_HUMAN | TNR6_HUMAN, BCLX_HUMAN |
| M3K2_HUMAN | IKKB_HUMAN, IKKA_HUMAN |
| PARP2_HUMAN | PARP1_HUMAN |
| ZN646_HUMAN | TRAF2_HUMAN |
| Q6LBI3_HUMAN | P53_HUMAN |
| Q9UD77_HUMAN | CASP8_HUMAN |
| Q5T3J6_HUMAN | P53_HUMAN |
| MX1_HUMAN | DAXX_HUMAN, E2AK2_HUMAN |
| BCR_HUMAN | P53_HUMAN, BCL2_HUMAN, E2AK2_HUMAN, BCLX_HUMAN |
| GORS2_HUMAN | TRAF2_HUMAN |
| Q6DC98_HUMAN | CASP6_HUMAN, CASP3_HUMAN, LAMA_HUMAN |
| Q2TB78_HUMAN | P53_HUMAN |
| TOP1_HUMAN | P53_HUMAN, E2AK2_HUMAN, PARP1_HUMAN |
| Q53QV1_HUMAN | TRAF2_HUMAN |
| SOX30_HUMAN | TRAF2_HUMAN |
| Q7Z6Q1_HUMAN | IKKB_HUMAN, IKKA_HUMAN, TRAF2_HUMAN |
| Q96EC6_HUMAN | BCLX_HUMAN |
| AP2C_HUMAN | P53_HUMAN |
| Q5T5T6_HUMAN | TRAF2_HUMAN, TNR1A_HUMAN |
| Q9BWP7_HUMAN | DAXX_HUMAN, P53_HUMAN |
| Q6DHV4_HUMAN | BID_HUMAN, IKBA_HUMAN |
| Q9UHB7_HUMAN | ACINU_HUMAN, TRAF2_HUMAN, LAMA_HUMAN |
| Q6FI29_HUMAN | BCLX_HUMAN |
| Q6IB95_HUMAN | TNF10_HUMAN, TR10B_HUMAN, TNFA_HUMAN, TRAF2_HUMAN, TNR1A_HUMAN |
| Q6IQ37_HUMAN | CASP7_HUMAN, CASP2_HUMAN, CASP3_HUMAN |
| CDC2_HUMAN | P53_HUMAN, BCL2_HUMAN, CASP3_HUMAN |
| UBE3A_HUMAN | P53_HUMAN |
| Q4VBQ6_HUMAN | P53_HUMAN |
| PP1A_HUMAN | P53_HUMAN, E2AK2_HUMAN, IF2A_HUMAN |
| Q4VXV6_HUMAN | P53_HUMAN |
| Q6B838_HUMAN | RIPK1_HUMAN, TR10B_HUMAN, CASP3_HUMAN |
| STK11_HUMAN | P53_HUMAN |
| GSPT1_HUMAN | TRAF2_HUMAN, BIRC4_HUMAN |
| Q5JTE6_HUMAN | FADD_HUMAN |
| PARVG_HUMAN | CASP3_HUMAN |
| Q6FGB5_HUMAN | P53_HUMAN |
| Q4VY20_HUMAN | BCL2_HUMAN, BID_HUMAN, BCLX_HUMAN, BAD_HUMAN |
| WT1_HUMAN | P53_HUMAN |
| IKBE_HUMAN | IKKB_HUMAN, IKKA_HUMAN, IKBA_HUMAN |
| DTNB_HUMAN | TRAF2_HUMAN |
| Q69BM0_HUMAN | BCLX_HUMAN |
| P2BA_HUMAN | BCL2_HUMAN, CASP3_HUMAN, BAD_HUMAN, IKBA_HUMAN |
| Q5VW83_HUMAN | BCLX_HUMAN |
| Q5JTE8_HUMAN | FADD_HUMAN |
| Q3SYD8_HUMAN | P53_HUMAN |
| Q53SE2_HUMAN | CASP6_HUMAN, BAK_HUMAN, CASP3_HUMAN |
| Q15959_HUMAN | DAXX_HUMAN, P53_HUMAN |
| Q5STB2_HUMAN | FAF1_HUMAN, TNFA_HUMAN, TNR1A_HUMAN |
| DYNA_HUMAN | CASP7_HUMAN, CASP2_HUMAN, CASP3_HUMAN |
| IRF4_HUMAN | BCL2_HUMAN, TRAF2_HUMAN |
| KPCZ_HUMAN | FADD_HUMAN, TNFA_HUMAN |
| FSTL1_HUMAN | TR10B_HUMAN, APAF_HUMAN |
| IL1B_HUMAN | CASP1_HUMAN |
| Q5SQL3_HUMAN | P53_HUMAN |
| ORN_HUMAN | BAD_HUMAN |
| RD23A_HUMAN | DAXX_HUMAN, TRAF2_HUMAN |
| Q86VR4_HUMAN | TRAF2_HUMAN |
| Q9NS56_HUMAN | P53_HUMAN |
| SYSM_HUMAN | CASP3_HUMAN |